To Analyse Usefulness of Immunohistochemical Analysis of Cell Block Specimens in Minimally Invasive Procedures of Pulmonary Lesions
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Many lung cancers present in an advanced stage and only cytology specimens or small biopsies are available for diagnosis. In modern era therapy for lung cancer is based on subtype of cancer. Immunohistochemistry done on cell blocks of pleural samples help in subtyping of lung cancers. In this study,immunohistochemical analysis on plasma thromboplastin cell blocks of cytology samples of pulmonary lesions received as pleural effusion, bronchial wash and guided FNA of lung lesions were included. A total of 100 cases were studied by plasma thromboplastin method. By cell block technique, cytology specimen were made into mini paraffin embedded biopsy materials which are available for immunohistochemistry . All the 14 cases diagnosed to be malignant on cell block by Hematoxylin and Eosin stain were confirmed and subtyped by immunohistochemistry. A panel of immunohistochemistry markers CK7, CK20, PanCK, Synaptophysin, p63,TTF-1,Calretinin and Estrogen receptor were used. This study showed confirmation of malignancy by immunohistochemistry on cell blocks on all cases (100%) of malignant pulmonary lesions. Subtyping of malignancy could also be done in 11 out of 14 cases (78%)
Authors and Affiliations
Dr. Arasi Rajesh1, Dr. Saranya2 . . . , , Dr. Johnsy Merla3*, Dr. Shantaraman4 . .
Keywords
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- EP ID EP365849
- DOI 10.9790/0853-1702161521
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