To Compare the Efficacy and Safety 2% Rebamipide, 0.18% Sodium Hyaluronate and 1% Carboxy Methyl Cellulose Eye Drops in Treatment of Mild to Moderate Dry Eye Disease
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: The purpose of this study to compare the efficacy and safety 2% rebamipide, 0.18% sodium hyaluronate and 1% carboxy methyl cellulose eye drops in treatment of mild to moderate dry eye disease. Patients with mild to moderate dry eye were enrolled in this randomized prospective study. They were divided into 3 following groups, patients in rebamipide group treated with 2% rebamipide 4 times daily, in SH group treated with 0.18% sodium hyaluronate 6 times daily and CMC group treated with 1% carboxy methyl cellulose 6 times daily. Fluorescein corneal staining, tear film breakup time, schirmer’s test, OSDI score and adverse reactions were assessed at baseline, 2weeks, 4weeks and 12 weeks after treatment initiation was done in this study. Sixty patients were allocated randomly in three groups, 20 patients in the rebamipide group, 20 patients in the CMC group, and 20 patients in the SH group. Three groups of drugs showed significant improvement in FCS, TBUT, schirmer’s test and OSDI score at 2week, 4 week and 12 week of initiation of treatment. However, rebamipide group was showed statistically significant differences in the above indices than the CMC and SH groups. There were no significant adverse reactions observed during follow up. 2% rebamipide, 0.18% sodium hyaluronate, and 1% CMC were effective in the treatment of mild to moderate dry eye. But 2% rebamipide was more efficacious than 0.18% sodium hyaluronate and 1% carboxy methyl cellulose.
Authors and Affiliations
Dr. Snigdha Sen, Dr. Krishna Kuldeep, Dr. Tirupati Nath, Dr. Maumita .
Keywords
Related Articles
- EP ID EP475261
- DOI -
- Views 193
- Downloads 0
A Study of Minimally Invasive Plate Osteosynthesis for the Treatment of Distal Tibial Fractures
Abstract: Distal tibial fractures are very common in orthopedic clinics; they are difficult to deal with and sometimes require operative treatments. Fixation with locking compression plate by minimally invasive percutane...
A Record Based Study of 3 Years of Routine PAP smears Screening with Follow up of All Abnormal Reports with Colposcopy and Biopsy
Abstract: Cervical cancer is the most common preventable cancers. Pap smear is simple, safe, cost effective screening test for detection of precancerous, cancerous changes in cervix. Any abnormality detected in PAP smear...
Measurement of Patient Dose in Vascular Intervential Radiography
Cardiac catheterizations have contributed greatly to the treatment of heart diseases. However the radiation exposure to the patient is significantly higher compared with other radiological examinations. The objectives of...
Heavy Metals Level Comparison in Blood of Industrial and Office Workers in Hail, KSA
Abstract: Increased use of pesticides and contaminated water in the agriculture in the modern society has highlighted on the putative role of metals in the development of chronic disorders in urban area. This study was c...
Clinico Radiological Presentation of Tuberculosis in Diabetes Patients
Abstract: The objective of the present study is to study the the clincal, radiological presentation of Tuberculosis in Diabetes patients. Theprospective observational study conducted in 50 patients with Diabetes andTub...