To compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2016, Vol 3, Issue 2
Abstract
Background & Objectives: Eperisone hydrochloride is a new drug came in market with centrally acting muscle relaxant, having additional vasodilator effect and used for treatment of backache associated with muscle stiffness like thiocolchicoside but supposed to be slightly better in efficacy and adverse effect profile. The aim of this study was to compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm. Methods: 100 eligible subjects were taken and assessment of severity of pain and muscle spasm was done by using Visual Analogue Scale, finger-to-floor distance (FFD), Lasegue’s maneuver and modified Schober’s test. Results: No statistically significant difference in pain relief and muscle spasm among both the treatment groups but clinically pain relief is slightly better in eperisone group. The adverse drug reactions occurring during study showed a slightly better safety profile in patients on eperisone than on thiocolchicoside. Conclusion: These findings confirm that eperisone represents a valuable and safer alternative to thiocolchicoside for treatment of low back pain associated with muscle spasm.
Authors and Affiliations
Seema Rani, Sanjeev Kumar, Joyti Joyti, Prem Kumar Verma, Dharvin Lamba, Rahul Saini
Keywords
Related Articles
- EP ID EP240599
- DOI -
- Views 110
- Downloads 0
Retrospective analysis on adverse drug reactions prevalence in the female population of Tertiary Care Hospital
Introduction Adverse drug reactions seems to be a major problem in women than menObjective This study as planned to assess the incidence rate clinical manifestations and causative agents for adverse drug reactions ADRs i...
Knowledge, attitude & perceptions of 3rd term medical students towards clinical trials in a medical college in southern India
Aim of the study: The present Study was performed to know the awareness of clinical trials and to assess the effectiveness of an educational intervention. Materials and Method: This was a questionnaire-based pre- and pos...
An exercise to sensitize undergraduate medical students about adverse drug reactions: An analysis
Introduction: Reporting of adverse drug reaction (ADR) is vital activity for the success of pharmacovigilance and healthcare professionals. The doctors play a pivotal role in the success of such activity. The one of the...
Mechanisms, Methods of Detection and Causality Assessment of Adverse Drug Reactions
Adverse Drug Reactions are very common cause of hospital morbidity
Evaluation of Efficacy of Nevirapine Regimen versus Efavirenz Regimen
Introduction: CD4 count can be used as marker to assess the effectiveness of antiretro viral treatment (ART), mortality and survival rates in HIV patients. It is an important guide to treatment as it reflects drug resist...