To Correlate Clinical Diagnosis with Histopathology and DIF Pattern of Autoimmune Based Vesiculobullous Disorders In A Tertiary Teaching Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Many skin diseases present with blisters but only in some of them blisters occur as the primary event. It is this group of disorders, which is traditionally termed the “vesiculobullous disorders”. Vesicle is a raised lesion filled with tissue fluid of size <5mm where as bullae is a raised lesion filled with tissue fluid of size >5mm. Definition of vesiculobullous disorders is some what arbitrary, because many other skin disorders which are definite entities may also exhibit blisters as one of the features of their presentation. Eg:. Eczema, impetigo, fungal and viral infections, EMF, insect bites, etc., Skin diseases grouped under the term “vesiculobullous” are considered to have an autoimmune basis with demonstrable antibodies directed against specific components of the skin. Excluded from this group of disorders is congenital epidermolysis bullosa which are due to specific gene defects. Aim: To correlate clinical / histopathological / immunological findings. Results: A total of 20 cases clinically diagnosed as Autoimmune Bullous dermatoses in both sexes attending the department of dermatology, in teaching hospital of Fathima Institute of Medical Sciences, kadapa, were selected for this study. Summary: Autoimmune Bullous dermatosis was more common in females. Around 30% of patients belonged to 51-60 age group. The mean age being 42.6. Bullous pemphigoid constituted 55% of all the Autoimmune Bullous Disorders studied, followed by Pemphigus vulgaris 25%.
Authors and Affiliations
Dr. P. SAILAJA
Keywords
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