To determine the treatment outcome in pulmonary tuberculosis patients who are detected Rifampicin Sensitive by Cartridge Based Nucleic Acid Amplification Test (CBNAAT)
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 3
Abstract
Background & objectives: India has the highest burden of tuberculosis in the world both in terms of drug sensitive and drug resistant TB and has a large impact on our economy. If we want to ensure control of the current situation with increasing numbers of resistant TB in the community, we need to ensure that the treatment regimens being given to our tuberculosis patients are efficient enough to control disease and thus avoid emergence of resistance. It has been noted that regimen for previously treated cases has a comparatively poor treatment outcome. This regimen is also against the basic principles of tuberculosis chemotherapy which says a single drug should not be added to a failing regimen. Hence, this study was planned to determine the treatment outcome in rifampicin sensitive patients which rules out the presence of resistance as the cause of decreased cure rates, and can thus effectively evaluate the effectiveness of the current regimens being provided to the tuberculosis patients under RNTCP. Methods: A prospective study was conducted at the Chest and TB hospital, Amritsar which included 100 patients diagnosed with sputum smear positive and rifampicin sensitive pulmonary tuberculosis. Treatment outcome was recorded at the completion of treatment as per the RNTCP guidelines for all patients. Treatment outcome was compared between new and previously treated cases and also its association with various other variables was seen. Results: Out of 100 study population, 27 were new cases and 73 were previously treated.Out of the 73 retreatment patients, 42(57.5%) were recurrent, 20(27.4%) were lost to follow up and 11(15.1%) were failure.14.8% of DOTS category I patient had unfavourable outcome whereas 38.4% of DOTS category II patients had unfavourable outcome and this difference came out to be significant (p< 0.05).
Authors and Affiliations
Dr. Naveen Pandhi1 , Dr. Balbir Malhotra2 , Dr. N. C. Kajal3 , Dr. Ashi Singh4 , Dr. Rajwinder Kaur5 , Dr. Amarendra K. Shukla6 , Dr. Lakhvir Kaur7 , Dr. Gurleen Kaur8 , N. S. Neki9
Keywords
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- EP ID EP563405
- DOI 10.22192/ijcrms.2018.04.03.018
- Views 115
- Downloads 0
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