To evaluate apoptotic and proliferative indices in premalignant and malignant squamous epithelial lesions of uterine cervix on light microscopy
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 6
Abstract
Introduction: The term apoptosis was first recognized in 1972 for its distinct morphology and named after the Greek term meaning “falling off”. Kerr, at University of Queensland was first to distinguish apoptosis (Greek: apo- from, ptosis – falling) from traumatic cell death and suggested the term apoptosis. Apoptosis is seen in various physiological and pathological conditions. Material and Methods: Haematoxylin and Eosin stained sections were used for morphology of the lesion and for evaluation of apoptotic and mitotic counts. Apoptotic index (AI) was calculated as the number of apoptotic cells and apoptotic bodies, expressed as a percentage of the total number of non- apoptotic tumor cells counted in each case. Results: Premalignant cases formed 46.29 % and malignant cases were 53.7 % of all lesions. Out of total malignant lesions, majority (69%) were of KSCC, and (31%) were of NKSCC. Discussion: In the present study, it was observed that there is an increase in mean AI, MI and TI with increasing grade of the lesion. AI, MI and TI progressively increased from CIN1 to CIN2 to CIN3 to SCC. Conclusion: It can be concluded that this study is based purely on morphology as it is fairly reliable, easily practiced and inexpensive method for detection of both apoptosis and mitosis
Authors and Affiliations
Dr Shairoly Singh
Keywords
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