To Evaluate the Effect of 17 Alpha Hydroxyprogesterone Caproate (17OHPC) As a Maintenance Tocolytic in Preterm Labor
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 9
Abstract
Aims & Objective- To evaluate the efficacy of of 17 alpha hyroxyprogesterone caproate after acute tocolysis with nifedipine in preventing preterm delivery. Material & Methods- It was a prospective clinical trial that was carried out on 100 pregnant females between 28- 34 weeks of gestation diagnosed with preterm labor pains All patients in pretrm labor were given nifedipine for acute tocolysis and antenatal corticosteroid was given to all patient for lung maturity. After tocolysis undelivered patients were randomly allocated to progesterone(n=50) and control group(n=50).Patients in Progesterone were given 17 alpha hyroxyprogesterone caproate, 250 mg, weekly and continued till 36 weeks of gestation or delivery, which ever occurred earlier. Control group were given nifedipine as a maintanencetocolysis as and when required. Results were analysed in terms of gestational age at delivery and neonatal outcome in both groups. Results-Mean gestational age at delivery was 35.2±2.3 weeks in progesterone group and 35.4±2.6 weeks in control group.It was statistically similar in two groups. Neonatal outcome was also found to be statistically similar in both groups.
Authors and Affiliations
Asma Nigar
Keywords
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