To Evaluate the Effect of Pre-Operative Oral Gabapentin on Cardiovascular Response to Laryngoscopy and Tracheal Intubation
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Background: Many pharmacologic approaches have been tried to obtund the haemodynamic response to laryngoscopy but none has been proved entirely satisfactory, because either the reflex is blocked incompletely or because the method itself carries some additional risk. Aims and Objective: Our study aims to assess the efficacy of oral Gabapentin 400mg in attenuating haemodynamic response to direct laryngoscopy and endotracheal intubation in ASA I/II normotensive patients undergoing elective upper abdominal surgeries under general anaesthesia. Materials and methods: A prospective, randomized, placebo controlled, double blind clinical study was conducted on 60 normotensive patients (30 in each group), of either sex, undergoing elective upper abdominal surgeries under general anaesthesia.Patients were randomized to C or G group accordingly and received the respective capsules, that is, the Placebo Capsule B-Complex or Capsule Gabapentin 400 mg, 2 hours prior to surgery. Results: As compared to Gabapentin group, control group patients showed significantly higher and sustained increase in heart rate, systolic and diastolic blood pressure, at 00 minutes immediately after intubation, 01, 03, 05, 10 minutes following intubation. The control group patients showed significantly higher and sustained increase in mean arterial pressure at induction and thereafter for 10 minutes (P < 0.001). Discussion: In our study, Oral route was selected as it is safe, less costly and more acceptable than the parenteral route. In our study, heart rate was less affected (12.38%) as compared to blood pressure (2.68%) and changes in diastolic blood pressure were minimal 2.65%. Conclusion: Gabapentin (400 mg), when given orally two hours prior to surgery effectively attenuates heart rate and blood pressure changes to direct laryngoscopy and tracheal intubation. Its effect on the heart rate is less as compared to blood pressure. Changes in diastolic blood pressure are minimal after intubation.
Authors and Affiliations
Dr Sumeet Chugh, Dr Shakti Singhal
Keywords
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- EP ID EP374256
- DOI 10.9790/0853-1705030914.
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