To Evaluate The Effects Of Tamsulosin, Solifenacin And Combination Therapy For The Treatment Of Urethral Stent Related Discomforts
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
INTRODUCTION: Despite the usefulness of stents in the modern urological practice,the patients experience various stent-related symptoms, such as pain, frequency, and urgency causing significant decrease in patient quality of life in both genders.Thus the pharmacologic management with selective alpha-1-blockers and antimuscarinic agents believed to be simpler and less invasive than other ways. AIMS & OBJECTIVES: To evaluate the effect of tamsulosin, solifenacin and combination therapy of the two agents in improving the lower urinary tract symptoms of patients with indwelling double-J ureteral stents. MATERIALS & METHODS:A total of 70 patients with ureteral stenting were randomly divided into 4 groups,group I no treatment(control group),group II received tamsulosin 0.4 mg daily, group III received solifenacin 10 mg daily, and group IV combination On preoperative day, postoperative day 1 and postoperative day 14, all patients completed the IPSS, quality of life and VAPS questionnaire. OBSERVATIONS & RESULTS: scores at pre-insertion and POD-1 in groups I to IV were nonsignificant.At 2 wks after insertion there was significant difference in scores with minimum score in combination therapy.The p value of IPSS scores including Storage symptom, Voiding symptom and Total scores at 2 wks post stenting in group II and III were nonsignificant.The storage symptom score was less in Group III compared to Group II (6.64 v/s 7.66)& the voiding symptom score was less in Group II compared to Group III( 4.84 v/s 5.12). CONCLUSIONS:. The combination therapy appeared to improve the VAS score, IPSS score and QOL at 2 wks after insertion as the values were significantly different from the control group and the individual groups. Thus combination therapy should be strongly considered for patients who complain of stent-related symptoms.
Authors and Affiliations
Dr Abhishek Shukla
Keywords
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- EP ID EP380941
- DOI 10.9790/0853-1708050116.
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