To Find out the Essentiality of Rv0526 Gene in Virulence of Mycobacterium tuberculosis by using In silico Approaches
Journal Title: Open Journal of Bacteriology - Year 2017, Vol 1, Issue 1
Abstract
Tuberculosis has emerged as a major world health problem, with almost one-third of the world population today infected with Mycobacterium tuberculosis H37Rv (M. tuberculosis). This gram-positive bacterium makes so many complications in its eradication completely. We need a proper way to inhibit its pathogenesis. Rv0526 (651bp/ 216 aa) is predicted to be a thioredoxin (Trx) like protein of Rv3673 family form a single transmembrane helix and show similarity to other M. tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677. Trx are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange, and it acts by its specific motif Cys37-Cys40 (CXXC). By using several bioinformatics tools, we may predict that Rv0526 may be an important component of cytochrome c maturation complex and show interaction with different other proteins. After knowing such specific features of this gene we may predict that mutational studies in Rv0526 gene may open new way towards the drug development.
Authors and Affiliations
Shivangi s, Beg Amjad, Meena Laxman S
Keywords
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- EP ID EP543213
- DOI 10.17352/ojb.000003
- Views 57
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