To Study and Evaluate the Various Aspects in Manufacturing Amorphous Spray Dried Dispersion.
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2017, Vol 5, Issue 3
Abstract
Spray-dried dispersions have become an significant formulation technology for the pharmaceutical product development of poorly water-soluble compounds. Even though this technology is now widely used in the industry, especially in the early-phase development, the lack of mechanistic understanding still causes difficulty in selecting excipients and predicting stability of SDD-based drug products. In this review, the authors aim to discuss various principles of polymer science pertaining to the development of SDDs, in terms of selecting polymers and solvents, optimizing drug loading, as well as evaluating physical stability on storage and supersaturation maintenance after dissolution. Spray drying of polymer-API solutions, low critical solution temperature was discussed for setting the inlet temperature for drying. The impact of polymers on the supersaturation creation and maintenance of APIs in dissolution media was also discussed. Moreover, the nature of SDDs, with reference to solid solution and the notion of solid solubility, was examined in the context of pharmaceutical application. Finally, the importance of robust analytical techniques to characterize the SDD-based drug products was highlighted, considering their complexity.
Authors and Affiliations
Tushar Suryavanshi| Pravara Rural College of Pharmacy, Rahata, DIstrict Ahmednagar, Loni Bk., Maharashtra 413736, India, Ramesh Bhusal| Pravara Rural College of Pharmacy, Rahata, DIstrict Ahmednagar, Loni Bk., Maharashtra 413736, India, Ravindra Fasale*| Pravara Rural College of Pharmacy, Rahata, DIstrict Ahmednagar, Loni Bk., Maharashtra 413736, India
Keywords
Related Articles
- EP ID EP1682
- DOI -
- Views 459
- Downloads 46
Enhancement of Hepatoprotective Effect of Herbal Formulation (F1) on Carbon tetrachloride and Ethanol Induced Liver Toxicity in Albino Rats
There are several plants and formulations which are recommended for the treatment of liver diseases. The formulation F1 was composed with Andrographis paniculata (Kalmegh), Boerhavia diffusa (Punarnava), Eclipta alba (Bh...
AN OVERVIEW OF EMERGING PHARMACOLOGICAL TARGETS IN TREATMENT OF TYPE 2 DIABETES MELLITUS
Diabetes is a chronic disorder which has serious complications if not treated appropriately. A number of therapeutic agents exist for the treatment of type 2 diabetes including metformin, sulfonylureas, thiazolidinedion...
THERAPEUTIC CONTACT LENS: A RECENT REVIEW
Therapeutic contact lenses (TCLs) have proved to be an effective tool in the management of a wide variety of ophthalmic disorders. Conditions recalcitrant to other treatment modalities may heal readily with the use of a...
Recent applications of nanodevices
Although the "war on cancer and other disease like AIDS" is now in its fourth decade and despite much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this d...
A suspected case of diphtheria, pertussis and tetanus vaccine (DPT) induced seizure in a paediatric patient
A 4-month old male child developed convulsions possibly following diptheria, pertusis (whooping cough), and tetanus (DPT) vaccine used for routine immunization. A diagnosis of vaccine induced seizures was made after ruli...