To Study of the Effect of Melatonin on Noradrenaline Mediated Behavioural Responses after Electroconvulsive Shock (ECS) Administration
Journal Title: MVP Journal of Medical Sciences - Year 2017, Vol 4, Issue 1
Abstract
Objectives: To look for possible data regarding the effects of melatonin on noradrenaline mediated behavioral responses after Electroconvulsive Shock (ECS) administration in rats. Methods: Forty rats were divided in four groups with ten rats in each group and treatment duration was kept for ten days in all the groups. 1. Control group- distilled water (2ml daily). 2. ECS pretreated group- Single ECS daily. 3. Melatonin group- melatonin suspension (10 mg/kg/day, p.o.) daily. 4. Test group- Single ECS daily + melatonin suspension one hour after ECS (10mg/kg/day, p.o). Clonidine induced sedation was used as a model to assess noradrenaline mediated behavioral changes. Clonidine induced sedation score was assessed 30 min after giving intraperitoneal injection of clonidine hydrochloride (100 μg/kg) in each group on day 11.Data was analysed by Mann-Whitney U test. Results: Findings show that administration of single ECS daily for consecutive 10 days results in enhancement of clonidine induced sedation. Melatonin administration decreases clonidine induced sedation which may be due to modulation at noradrenergic neurotransmission. Also, melatonin significantly retarded the ECS-induced enhancement of clonidine induced sedation. Conclusion: ECS administration leads to enhancement in clonidine induced sedation. Melatonin administration could prevent enhancement in clonidine induced sedation which may be due to modulation at the level of noradrenergic transmission. This modulation in noradrenergic transmission might be of some value in attenuation of disruption of memory following ECS administration. As ECT in humans is known to produce memory disruption, a possible potential therapeutic utility of melatonin to prevent memory disruption in such patient is worth considering.
Authors and Affiliations
Jeetendra Singh, Tushar C. Baheti, Sunil Patil
Keywords
Related Articles
- EP ID EP430749
- DOI 10.18311/mvpjms/2016/v3i2/11050
- Views 111
- Downloads 0
Structured Oral Examination as an Assessment Tool for Third Year Indian MBBS Undergraduates in Community Medicine
Introduction: Traditional viva are useful in assessing depth of knowledge and overall communication skill of student but demerits are many such as unequal time distribution for viva, gender bias, non uniformity, examiner...
Study of Serum Alkaline Phosphatase Levels among Psoriasis Patients and Comparative Group in Tertiary Care Institute
Background: Psoriasis is a chronic relapsing autoimmune skin disease of unknown etiology, characterised by complex alterations in epidermal growth and differentiation. Oxidative stress is a known risk factor for exacerba...
A Descriptive Study on Patients of Papulosquamous Lesion at Tertiary Care Institute
Background: Papulosquamous lesions of the skin are encountered with considerable frequency. There is overlap of both clinical pattern and distribution of papulosquamous skin disorders, which often makes clinical diagnosi...
Astigmatism Correction in Cataract Surgery with Foldable Toric IOL
Aim: To evaluate correction of pre-existing astigmatism after foldable Toric IOL implantation in patients undergoing cataract surgery. Materal & Methods: In this prospective observational study we included 10 eyes of 10...
Study of Split Thickness Skin Grafting in Management of Post Burn Contracture
The aim of the study is study outcome of patients undergoing split thickness skin grafting for post burn contracture release. Material and Methods: All patients of post burn contracture admitted to medical between August...