To Study the Effect of Methanolic Extract of Capparis decidua (Kair) on Oxidative State of Liver in Diabetes Induced Wistar Albino Rats
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2018, Vol 0, Issue 0
Abstract
Type-1 diabetes is a chronic disorder characterized by the body’s inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. The liver plays a essential role in the regulation of metabolism of carbohydrate. The core mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an anomalous inflammatory response. The aim of this study was to examine hepatoprotective effects of methanolic extract of Capparis decidua (CDMtE) against oxidative stress in streptozotocin (Stz) induced diabetic albino rats. A dose dependent effect was evaluated to elucidate relative responses of reactive oxygen species. Animals were divided into five groups i.e. Group I: Control; Group II: Diabetic control; Group III: Stz + 100 mg/kg CDMtE; Group IV: Stz + 200 mg/kg CDMtE; Group V: Negative Control treated with glibenclamide. Two different doses of Capparis decidua methanolic extract (i.e. 100 and 200 mg/kg body weight) were administered orally for 3 weeks. Following euthinization glycogen, glutathione, LPO, SOD and catalase were measured in liver. In this study no significant variation was observed in level of antioxidants for Group IV and Group V (P>0.05) when it was compared to Group I. Dose containing 200 mg/kg body weight of CDMtE showed greater ability to elevate level of antioxidants in liver. Our study showed that administration of 200 mg/kg body weight of CDMtE completely resumes level of antioxidants in liver of diabetic rats
Authors and Affiliations
Charuta Mathur, R S Gupta
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