To study the efficacy and safety of combination treatment using allopurinol and fenofibrate in patients with hyperuricemia
Journal Title: Pakistan Journal of Pharmacology - Year 2012, Vol 29, Issue 1
Abstract
Allopurinol is the most frequently used antihyperuricemic drug. Fenofibrate, a derivative of fibric acid, is commonly used in the treatment of hyperlipidemia. Fenofibrate treatment has been shown to decrease serum urate levels. This study was conducted to compare the efficacy and safety of combination treatment using allopurinol 100mg and fenofibrate 67mg daily with allopurinol 300mg daily. Sixty hyperuricemic patients with serum uric acid level 7.0mg per deciliter or above were enrolled and assigned to take either allopurinol 300mg or combination treatment using allopurinol 100mg + fenofibrate 67mg daily for 12 weeks. Drug efficacy was assessed by measuring percentage of subjects achieving serum uric acid level less than 6mg per deciliter at day 90. Drug efficacy was also assessed by measuring percent change in serum uric acid level from day 0 to day 90. Safety of the drug was assessed by reviewing adverse effects (AEs) and laboratory values. Comparison of percentage of subjects reaching serum uric acid level less than 6.0mg per deciliter at day 90 between the two groups was highly significant (P=0.001). Similarly percent change in serum uric acid level from day 0 to day 90 was also highly significant between the two groups (P=0.001). Our results showed that allopurinol 300mg once daily is more effective than combination treatment using allopurinol 100mg plus fenofibrate 67mg. However proportions of subjects experiencing any adverse event were higher in allopurinol 300mg group. Similarly the adverse effects leading to treatment withdrawal were higher in allopurinol group. Allopurinol 300mg once daily is more effective antihyperuricemic agent than combination treatment using allopurinol 100mg plus fenofibrate 67mg.
Authors and Affiliations
Irfan Zafar, Moosa Khan, Abdul Junejo, Syeda Zain
Keywords
Related Articles
- EP ID EP114757
- DOI -
- Views 103
- Downloads 0
Prevalence of HCV genotypes in patients reporting in tertiary health care hospital of Karachi
The present study was designed to see the variables which may affect the conventional treatment outcome by injection interferon in chronic hepatitis “C” patients. Among these variables hepatitis “C” genotype is most impo...
Daily iron supplementation results in greater increase in red blood cell volume while intermittent iron results in greater increase in hemoglobin level in iron deficiency anemia of pregnancy
This study aimed to evaluate the relative effectiveness of two different oral iron regimens on hematological parameters in anemic pregnant women. Study was longitudinal & randomized .Total 160 anemic women attending...
Interferon (IFN a) induced depression in patients of hepatitis C (HCV)
HCV is a global problem and the worst affected are the 3rd world countries. In our study of 802 patients 244 male and 161 females were positive for HCV. Majority of the patients were in age group 26-40 Years i-e 56.04% o...
Effectiveness of weekly iron supplementation in anemia in pregnancy
Iron deficiency has been a serious health issue especially in pregnancy. Various studies now consider daily iron as an excessive source of iron supply. In present study we compare effectiveness of daily verses weekly iro...
Influence of cigarette smoking on lipid profile in male university students
There is much controversy about which components in the lipid profile are mainly altered in response to cigarette smoking, and whether those lipid profile components influence other parts directly or indirectly and vice...