To Study the Efficacy and Side Effects of Drotaverine and Epidosin (Valethamate) in Acceleration of Labor and to Study their Effects on the Fetal Outcome
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 11
Abstract
Background: Labor is the most perilous journey a woman has to undertake. Painless and short labor is desired by every woman and is a constant aim for obstetrician. Objectives: To study the efficacy and side effects of Drotaverine and Epidosin (Valethamate) in acceleration of labor and to study their effects on the fetal outcome. Purpose: This study was undertaken to compare effectiveness of Drotaverine and Epidosin in acceleration of labor. Method: The present study is a prospective comparative study conducted at Raipur Institute of Medical Sciences. Raipur. from October 2014 to September 2016 over a period of 2 years. 150 antenatal women with 38-41 weeks of gestational age were included in study and were divided into three groups randomly. Group V consisted of 50 women who received Valethamate, group D consisted of 50 women who received Drotaverine and Group C also consisted of 50 cases who received normal saline. Various parameters of duration of labor, mode of delivery, maternal and fetal complications and side effects of these drugs were compared in three groups. Results: The present study showed that both the drugs shorten the duration of first stage of labor when compared to control, but Drotaverine reduces the duration more than Valethamate bromide. Both in primi and multi this difference was statistically significant. There was no significant difference in duration of second and third stages of labor in between the three groups. Mode of delivery, neonatal outcome were almost similar in the three groups. Minor side effects were more common in Valethamate group than in Drotaverine and control group. Conclusion: Drotaverine is found to be better than Valethamate in shortening the duration of labor with less side effects. Both the drugs have no major side effects and have good fetomaternal outcome. Thus these drugs are safe, potent and effective drug to be used in active phase of labor.
Authors and Affiliations
Dr Neerja Agarwal
Keywords
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