To Study the Prevalence of Microalbuniuria in Amyloid Positive and Negative Patients of Rheumatoid Arthritis
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 11
Abstract
Introduction: Rheumatoid arthritis (RA) is a common, chronic, inflammatory, autoimmune disease of unknown etiology affecting approximately 1% of the world population. Current research aimed to study the prevalence of microalbuniuria in amyloid positive and negative patients of rheumatoid arthritis(R.A). Material and methods: The present study Cross-sectional study was carried out on rheumatoid arthritis patients at Department of Medicine, Chhatrapati Shivaji Subharti Hospital (C.S.S.H), Meerut. RA patients with disease duration > 3 years were included in this prospective study over a 2 year period. All the patients underwent Urine (routine/microscopic) evaluation and urinary Albumin, Creatinine assessment was done to calculate Albumin/Creatinine ratio (ACR). The patients were divided in two groups Group I (n=13) positive for amyloid and Group II (n=87) negative for amyloid. Results: Proportion of those with urinary albumin levels in + and ++ category was significantly higher in Group I (69.2%) as compared to that in Group II (14.9%) (p<0.001). Mean urinary ACR was significantly higher in Group I (73.83+31.64) as compared to that in Group II (31.44+14.41) (p<0.001). Patients with subclinical amyloidosis had significantly higher urinary albumin and ACR ratios as compared to those without it. Conclusion: The study concludes that presence of microalbuminuria indicates severe disease activity and longstanding rheumatoid arthritis. Also microalbuminuria is a sensitive indicator of increased renal vascular permeability in Rheumatoid Arthritis patients
Authors and Affiliations
Nishant Wadhera, Girish Dubey, Abhishek Gupta, Mamta Gupta, Sneha D. Vishwasrao, Sachin Kumar
Keywords
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