To Study the Prevalence of Non Alcoholic Fatty Liver Disease among Overweight and Obese Persons Undergoing Preventive Health Checkups in a Tertiary Care Hospital
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Introduction: Raised Body Mass Index (BMI) is on an increasing trend nowadays, associated with various complications. The present study was planned to determine the prevalence of Non Alcoholic Fatty Liver Disease (NAFLD) among overweight and obese persons undergoing preventive health checkups and to compare the various risk factors among NAFLD and non-NAFLD population at a tertiary care center in north India. Methods: A hospital based prospective study was done on 200 persons both male and female with BMI >23 kg/m2 according to WHO criteria for the Asians. They underwent a detailed history and clinical examination, blood examination including sugar levels, serum lipid profile and liver function tests along with ultrasonographic (USG) examination for hepatobiliary system. Results: Out of 200 persons having BMI >23 kg/m2 , 130 (65%) were males and 70 (30%) were females. Ultrasonography revealed NAFLD in 114 persons (57%) out of which 68.4% were males and 31.5% were females with mean age of male 45.88+/-49 years and of female 46.40+/-11.43 years. NAFLD in overweight category was 50.7% and among obese was 70.9% (p=0.007). Prevalence of risk factors among NAFLD persons was significantly higher than the non NAFLD group with 50.8% (p=0.024) having systolic blood pressure≥130mmHg, 43.8% (p=0.002) having diastolic BP ≥ 85mmHg, 50.8% (p=0.001) had fasting sugar ≥ 100mg/dl and ALT was found to be elevated in 54.3% (p=0.006) of subjects. Conclusion: It can be concluded from our study, earlier the discovery of fatty liver in routine checkups was considered to have no significance but now it is well established that obesity is a high risk factor for development of NAFLD. Other risk factors like raised blood pressure, elevated fasting sugar and serum triglyceride and low HDL levelsmay be associated in these patients which may further lead to NAFLD. These risk factors are preventable and reversible
Authors and Affiliations
Smita Gupta
Keywords
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