TO STUDY THE ULCEROPROTECTIVE EFFECT OF LEAVES OF MORINGA OLEIFERA ON EXPERIMENTALLY INDUCED INFLAMMATORY BOWEL DISEASE ON ANIMAL MODELS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 8
Abstract
Objective: The present study was carried out to evaluate the ulceroprotective effect of ethanolic extract of leaves of Moringa oleifera (EEMO) on experimentally induced inflammatory bowel disease (IBD) on Albino (Wistar strain) rats. Methods: The rats were divided into four groups of six animals each. Group A and Group B received gum acacia per orally (P.O.), Group C received EEMO in dose of 500 mg/kg/day P.O., and Group D received 5-aminosalicylic acid (5-ASA) in the dose of 100 mg/kg/day P.O. All the animals were pre-treated with respective drugs (volume of drugs was kept constant at 10 ml/kg) for 5 days, along with the normal diet. On 5th day, animals were kept fasting for 12 h (overnight), and IBD was induced next morning in Groups B, C, and D by the administration of 1 ml of 4% acetic acid solution transrectally (TR). Group A (normal control) received 0.9% normal saline TR instead. Results: The results have been shown that EEMO has significant activity against experimentally induced IBD when compared to the experimental control, with near normalization of colon architecture both macroscopically as well as microscopically. Tissue oxidative stress was reduced with significant improvement in tissue levels of superoxide dismutase (SOD) and catalase (CAT). Furthermore, significant improvement in levels of myeloperoxidase (MPO) was observed. Conclusion: It is concluded that EEMO has got potent activity against experimentally induced IBD due to its anti-inflammatory and antioxidant properties.
Authors and Affiliations
SHIPRA KAUSHIK , SHOBHIT KAUSHIK
Keywords
Related Articles
- EP ID EP636142
- DOI -
- Views 99
- Downloads 0
INTERPENETRATING POLYMER NETWORK IN DRUG DELIVERY FORMULATIONS: REVISITED
Interpenetrating polymer network has gained a lot of interest in drug delivery system due to its ease of modification during its synthesis and development state, which evolved novel physicochemical and mechanical propert...
GUAVA LEAVES, CORN COBS, AND MANGOSTEEN PEELS AS ANTIOXIDANTS AND NATIONAL STANDARDIZED NATURAL PRESERVATIVES FOR COCONUT BROWN SUGAR
Objective: Below standard brown sugar is a sugar that cannot be made or resembles dodol (a traditional and sticky confection) because the sap is damaged. Although the sap is made into brown sugar, the product will not la...
ANTIOXIDANT, ANTIBACTERIAL, AND ANTICANCER ACTIVITY FROM MARINE RED ALGAE GRACILARIA EDULIS.
Objective: The marine seaweed Gracilaria edulis was collected from Rameshwaram Mandapam coast. The main objective of G. edulis was to check about the antioxidant, antibacterial, and anticancer activity. The potential use...
THE ROLE OF SELENIUM MICRONUTRIENTS AS ANTIOXIDANTS IN EXPOSURE TO E-CIGARETTE SMOKE
Objective: E-cigarette products have resulted in various controversies concerning their posed impacts on health. Some argue that exposure to e-cigarette smoke could improve free radicals in the body; thus, it causes harm...
AUTOINDUCTION PROPERTIES OF RIFAMPICIN ON JAVANESE TUBERCULOSIS WITH VARIANT TYPE CYP3A4*1G
ABSTRACTRifampicin is one of the first-line anti-tuberculosis drugs. Rifampicin is metabolized by cytochrome P450 (CYP) 3A4. Polymorphisms of the CYP3A4gene will affect gene expression. This leads to impaired of formatio...