TOBACCO USE AND ITS RELATION TO RAISED TOTAL IGE CONCENTRATION AND INCREASED RISK OF TYPE 1 HYPERSENSITIVITY REACTION AMONG MALES IN KHARTOUM, SUDAN
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 1
Abstract
Background: Continued tobacco use has been shown to affect both humoral and cellular immune responses. Cigarette smoke as well as other tobacco forms impairs the integrity of the lung epithelial layer and facilitates the penetration of allergens by compromising the innate defense mechanisms in the lungs. Thus, smoking may be stated to induce predisposition to atopy. Symptoms of cigarettes allergy are similar to asthma which includes, shortness of breath, wheezing, coughing and impaired lung function. Objectives: To investigate the effect of different tobacco products on serum total IgE concentration among healthy males in Khartoum, Sudan. Materials and methods: This prospective case control study was conducted in Khartoum, Sudan and involved 119 healthy males who age between (18-35) years. Study subjected were classified into five groups: 19active smokers, 13water pipe smokers, 18 smokeless tobacco users, 22 passive smokers and 35 non-tobacco users (controls). Demographic data was collected from each participant in a data collection sheet and a written informed consent was obtained from all participants. Serum samples were analyzed quantitatively using The ELISA test kit for detection of human antibodies of the IgEclass. Results: A tremendous increase in IgE mean SD level have been demonstrated among tobacco consumers (302±154) compared to non-users, mean SD level (120.5±143), and this elevation was more obvious among males who use combination of all three forms of tobacco (415±500). Conclusion: This study concluded that tobacco use among Sudanese males could be on of today's leading public health problems and may play a major role on the progression of hyper sensitivity reactions and allergic responses.
Authors and Affiliations
Rasha Elbushra Abdulhameed
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