Abstract

Liposomes are colloidal particles formed as concentric bimolecular layers that are capable of encapsulating drugs. Liposomes have the potential for extending the duration of action for days or months. Tolnaftate is is used as the topical antifungal agent. The purpose of this study was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability. In present study, four different liposomes formulations of Tolnaftate were prepared by ethanol (solvent) injection method by varying the concentrations of phospholipids. The prepared liposomes were characterized for size, shape, entrapment efficiency, zeta potential, in-vitro drug release. An in vitro drug release of about 82.114 % in 10 h was observed from optimum formulation of batch LS4. Keywords: Tolnaftate, liposomes, phospholipid, entrapment efficiency, zeta potential, in-vitro drug release

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