Topical Application of Lactobacillus plantarum on Burn Wound Healing in Diabetic Rats

Journal Title: Iranian Journal of Veterinary Surgery - Year 2019, Vol 14, Issue 1

Abstract

Objective- This study was designed to investigate the effect of Lactobacillus plantarum gel on cutaneous burn wound healing in diabetic rats. Design- Randomized experimental study Animals- Forty adult male rats Procedures- Two circular 1 cm cutaneous wounds were created in the dorsum back of each rat. 48 h post-burning, debridement with a 1 cm biopsy punch was performed. The wounds were divided into the following four treatment groups (n= 10, each): 1. Untreated or negative control (NC), 2. silver sulfadiazine (positive control-SSD), 3. base gel (BG) 4. Lactobacillus plantarum Gel (LP gel). The wound surface area and epithelialization were monitored. The animals were euthanized at 10 (n = 5), and 20 (n = 5) days post-injury (DPI) and the skin samples were used for histopathological, biochemical, TGF-β gene expression and biomechanical investigations. Results- It was indicated that the L. plantarum and SSD treated lesions had the lowest percentage of wound size and collagen content and also the L. plantarum treated group showed shortest inflammatory period and highest amount of TGF-β at 10 days post injury. The L. plantarum gel treated lesions also demonstrated greater ultimate load compared to the untreated and based gel treated wounds. Conclusions and Clinical Relevance- In conclusion, L. plantarum gel therapy improved wound healing and resulted in better outcomes after severe burn injury in diabetic rats compared with the silver sulfadiazine treatment.

Authors and Affiliations

Keywords

Related Articles

Diagnostic Imaging Features of Haemangiopericytoma at Presumed Location of Vaccine-Site in a Dog: A Report of a 13 Years Old Spitz

Case Description- A 13 years old neutered female spitz dog was presented to the Small Animal Veterinary Teaching Hospital, University of Tehran for appearance of a soft tissue mass in the interscapular region in about 9...

Benidipine Reduces Ischemia/Reperfusion Injury Following Testicular Torsion/Detorsion in Rats

Objective-This study aimed to determine the protective effects of benidipine on testicular injury after testis torsion/detorsion in ratsDesign-Experimental study Animals-Fifteen male Sprague-Dawly rats weighing 200-220g...

Surgical Treatment of Uterine Prolapse in a Mare: Clinical Report

Case Description- A 6-year-old mare suffering from uterine prolapsed was presented to the veterinary clinic. The uterus was prolapsed 4 hours following a normal foaling. Clinical Findings- Initial evaluations of the uter...

A Rare Urinary Bladder Fibrosarcoma with a Cystolith in a Dog

Case description: This report describes the simultaneous occurrence of fibrosarcoma and a urolith in the urinary bladder of a 12-year-old female terrier dog that was confirmed by pathology after excisional surgery. Clini...

Development of Risedronate-Loaded Nano Capsules for Calvaria Healing in Rabbit

Objective- Bone regeneration is a multifactorial phenomenon which contributed to several factors. It is reported that risedronate is effective for musculoskeletal diseases. The current study was to determine effectivenes...

Download PDF file
  • EP ID EP591443
  • DOI 10.22034/IVSA.2019.171577.1173
  • Views 161
  • Downloads 0

How To Cite

(2019). Topical Application of Lactobacillus plantarum on Burn Wound Healing in Diabetic Rats. Iranian Journal of Veterinary Surgery, 14(1), 60-72. https://europub.co.uk/articles/-A-591443