Total protein level of plasma donors in various regions of China: a survey of 1 373 cases
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 1
Abstract
Objective To analyze the influence of plasma donation on human total protein level and the impact of different blood collection tubes on total protein level detection. Methods A total of 1 373 plasma donors from 11 apheresis plasma stations in 6 provinces/autonomous regions from March to April, 2021 were selected. Whole blood was collected by ordinary blood collection tube without anticoagulant, heparin anticoagulant tube and sodium citrate anticoagulant tube, and then respectively divided into serum group, heparin anticoagulant group, and sodium citrate anticoagulant group. After separating serum and plasma, the samples were subjected to total protein detection using the biuret method. Kruskal-Wallis test was used to compare the total protein levels among different tubes. The plasma donors were divided into male group (n=597) and female group (n=776), and the total protein levels between different genders were compared by t test. The plasma donors were divided into Sichuan group, Hubei group and Gansu group according to the region, and the Games-Howell test was used for comparison. Results The median serum total protein level of 1 373 donors was 73.1g/L, which was consistent with the reference range of 65-85 g/L. The median total protein levels of the serum group, heparin anticoagulant group and sodium citrate anticoagulant group were 73.1g/L, 73.3g/L and 63.8g/L, respectively, with statistically significant difference (P<0.05). There was statistical significance in total protein level between sodium citrate anticoagulant group and serum group, sodium citrate anticoagulant group and heparin anticoagulant group(P<0.05), but no statistical significance was noticed between serum group and heparin anticoagulant group (P> 0.05). The serum total protein levels of male group and female group were (72.41±5.40)g/L and (73.67±4.95)g/L, reseectively, and the difference was statistically significant (P<0.05). The serum total protein level in Sichuan group, Hubei group and Gansu group was (73.91±4.29)g/L, (74.17±5.11)g/L and (67.09±3.65)g/L, respectively (P<0.05).The difference between Gansu group and Hubei group, Gansu group and Sichuan group was statistically significant (P<0.05), but no significant difference was noticed between Sichuan group and Hubei group (P>0.05). Conclusion Plasma donors who meet the donation criteria will not experience abnormal total protein levels due to regular plasma donation. There were differences in total protein levels among different blood collection tubes, different genders and different regions. The total protein level of females was higher than that of males. The total protein level was the highest in Hubei province, followed by Sichuan and Gansu.Heparin anticoagulant group was the highest, followed by serum group and sodium citrate anticoagulant group.
Authors and Affiliations
Yang GAO, Rong ZHOU, Hongfang YANG, Liyi HAN, Rong HUANG, Yan HANG, Demei DONG
Keywords
Related Articles
- EP ID EP738743
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.01.010
- Views 40
- Downloads 0
Acute normovolemic hemodilution autologous blood collection with two pumps linked automatic equipment and its influence on hemodynamic parameters in laboratory animals
Objective To explore the effect and feasibility of using two pumps linked automatic equipment to collect autologous blood of acute normovolemic hemodilution (ANH) in improving blood collection speed, accurately controlli...
Detection results of blood donors with HBsAg reactivity to single reagent: a retrospective analysis
Objective To retrospectively analyze the detection results of blood donors with HBsAg reactivity to single reagent detected by enzyme-linked immunosorbent assay (ELISA) in our center, so as to provide basis for further c...
Serological characteristics and molecular mechanisms of occult hepatitis B virus infection in blood donors
[Objective] Abstract: Objective To analyze the serological characteristics of occult hepatitis B virus infection (OBI) in blood donors, and to explore the molecular mechanism of HBV S gene mutation in the immune escape o...
Evaluation and influencing factor analysis of the detection effect of hepatitis B virus surface antigen and treponema pallidum using rapid screening immunochromatography technology
Objective To evaluate the effectiveness of rapid initial screening using HBsAg and syphilis reagents of immunochromatography technology before blood donation, and explore the influencing factors. Methods The pre-donation...
Demographic difference and influencing factors of motivations between whole blood and plasmapheresis donors: a comparative study
Objective To explore the difference of demographics and influencing factors of motivations between whole blood donors and plasmapheresis donors, so as to provide scientific reference for effective recruitment strategy. M...