Toxic epidermal necrolysis
Journal Title: Reumatologia - Year 2006, Vol 44, Issue 6
Abstract
Toxic epidermal necrolysis (TEN, Lyell’s syndrome) is a life-threatening disease of the epidermis and mucous membranes, appearing after exposure to certain drugs. The metabolites of drugs produced in keratinocytes activate the in situ synthesis of TNF-α followed by the process of apoptosis. The symptoms of TEN are erythema multiforme, flaccid bullae and epidermal necrosis followed by massive loss of epidermis of skin and mucosa as well. TEN mortality rate is between 30% to 40%. The therapy of TEN patients includes monitoring of fluid balance and the prevention of systemic infections. Specific therapy for TEN (corticosteroids, cyclosporin A, cyclophosphamide, iv immunoglobulin) is still controversial.
Authors and Affiliations
Mariusz Puszczewicz, Marta Ociepa-Zawal
Keywords
Related Articles
- EP ID EP149607
- DOI -
- Views 63
- Downloads 0
Zastosowanie przeciwciał monoklonalnych przeciw limfocytom B w terapii reumatoidalnego zapalenia stawów
W ostatnich latach nasza wiedza o udziale limfocytów B w patogenezie reumatoidalnego zapalenia stawów uległa znacznemu poszerzeniu. Obecnie uważa się, że limfocyty B odgrywają zasadniczą rolę w rozwoju reumatoidalnego...
Some aspects of pharmacotherapy of low back pain connected with degererative spine disease
Pain disability in the course of degenerative spine disease produces the pathological deterioration of quality of life and ability to work. Pain is usually associated with changes of the spinal motion segment and part of...
Szósta Narodowa Konferencja Albańskiego Towarzystwa Medycyny Wewnętrznej Tirana 28–29 czerwca 2006 r.<br />
The influence of weather on articular complaints of patients with rheumatoid arthritis
The aim of the present work was estimation of influence of temperatures, air humidity and atmospheric pressure on complaints of patients suffering from rheumatoid arthritis (RA). In investigation participated 50 outpatie...
Sjögren’s syndrome in patient with CFTR mutation gene. Case report and review of literature
Sjögren’s syndrome is a systemic, chronic autoimmune disease in which pancreatitis may appear. Here we present 21-year-old woman, with mutation of cystic fibrosis gene, recurrent pancreatitis, leucopenia and hipergamm...