Toxicity potentials of <i>senna podocarpa</i> (guill.et perr.) lock pods in rodents
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 3
Abstract
The effects of acute (LD50) and sub-chronic doses of the aqueous infusion of [i]Senna podocarpa[/i] (Guill. et Perr.) Lock pod on the liver, kidney, brain and testis of mice and rats were studied, respectively. The acute toxicity studies did not produce any observable lethal effects and the calculated LD50 was 6.6 g/kg. The histopathological analysis of the liver, kidney, brain and testis showed no adverse effect. Behavioral observations and the histopathological findings did not show significant differences between the control and the treated groups. There were no marked adverse alterations or degeneration of tissues since these vital organs showed normal architectures suggesting no morphological disturbances as compared with the control group. The findings indicated that the aqueous infusion of [i]S. podocarpa[/i] pod was devoid of overt acute and sub-chronic toxic effects in mice and rats.
Authors and Affiliations
M. Akanmu, E. Iwalewa, A. Elujoba, K. Adelusola
Keywords
Related Articles
- EP ID EP96440
- DOI -
- Views 163
- Downloads 0
A survey of treatment practices for febrile illnesses among traditional healers in the nigerian middle belt zone
This survey was conducted to investigate the pattern of treatment practices for febrile illnesses among one hundred and eighty five traditional healers from the Nigerian Middle belt zone ethnomedicine. Data collection wa...
IN VITRO AMOEBICIDAL ACTIVITY OF SOME MEDICINAL PLANTS OF THE BAMUN REGION (CAMEROON)
Fifty two medicinal plants belonging to different families selected on the basis of their traditional use against jaundice and various liver disorders were tested for their amoebicidal activities. They were extracted an...
Are the institutions ready to empower local herbalists?
ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF HEMIDESMUS INDICUS ROOT EXTRACT
The methanolic extracts of Hemidesmus indicus (Asclepiadaceae) root (100, 200 and 400 mg/kg orally) were tested in carrageenan-induced rat paw oedema and brewer’s yeast-induced pyrexia in rats to assess their anti-inflam...
Piscicidal activity of alcoholic extract of nerium indicum leaf and their biochemical stress response on fish metabolism
Laboratory evaluations were made to asses the piscicidal activity of ethyl alcohol extract of Nerium indicum leaf against predatory fish Channa punctatus and their ultimate mode of action on fish metabolism. Toxicity ex...