Toxicological evaluation of Commiphora swynnertonii stem bark exudates on mice and rats
Journal Title: Journal of Biodiversity and Environmental Sciences (JBES) - Year 2017, Vol 11, Issue 1
Abstract
The aim of this study was to evaluate the safety of Commiphora swynnertonii stem bark exudates by determining its acute and sub-acute toxicity in mice and rats. The acute toxicity of exudates was administered to mice by oral administration of a single dose of tested concentrations and observed for 14 days. The doses were 500, 1000 and 3000mg/Kg body weight. The sub-acute toxicity test of the exudate was conducted on rats through a daily oral administration of various doses for 28 days. The doses were 250, 500 and 1000mg/Kg body weight. The physiological, behavioral and body weight change as well as relative weight of internal organs were subsequently recorded. Hematological, biochemical and histopathological parameters for rats used in the sub-acute toxicity assay were also measured at day 28. Results showed that, administration of up to 3000 mg/Kg body weight the C. swynnertonii exudates in mice did not result into any observable toxicity or mortality within the period of 14 days. Furthermore, the sub-acute toxicity test revealed that the exudates did not induce mortality neither behavioral nor physiological changes after 28 days. It was further observed that, the rat’s body and relative internal organs weight as well as hematological, biochemical and histopathological parameters did not change as results of receive the doses for the whole period of the study. Therefore this study has revealed that C. swynnertonii stem bark exudates is safe for oral administration at low and moderate doses.
Authors and Affiliations
Sylvester G. Temba, Paul Erasto, Disela E. Swai, Musa Chacha
Keywords
Related Articles
- EP ID EP39213
- DOI -
- Views 194
- Downloads 0
Phylogenetic relationships between Trigonella species (Bucerates section) using ITS markers and morphological traits
Trigonella L. (Fabaceae) includes about 135 species worldwide and most of the species are distributed in the dry regions around Mediterranean. Phylogenetic relationships of 18 species of medicagoid and one representativ...
Contribution to comparative study of the physico-chemical quality of waters of Moulouya and Ansegmir rivers in upstream of Hassan II dam (Province of Midelt, Morocco)
The hydrographic network of the watershed of lake of Hassan II Dam (Midelt, Morocco) is fairly well developed. This latter is mainly represented by rivers Moulouya and Ansegmir, whose flows are virtually permanent. With...
CO2 aplication as growth stimulator of seagrass, Thalassia hemprichii under laboratory condition
Seagrass study needs to be continuously developed in order to know its potentiality of storing carbon. One of the studies uses carbondioxide (CO2) as growth rate indicator of the seagrass, Thalassia hemprichii, in a con...
The creation of geo-tourism infrastructure and a strategy for conservation and sustainable development of Qeshm Geopark
Geotourism is defined as geographical tourism which implicitly emphasizes geological and geomorphological features as the background of all human activities and geographical characteristics. However, it also has cultura...
The effect of auxin foliar spray on qualitative traits of forage sorghum var. speed-feed under water deficit stress
In order to study the effect of water deficit stress and different levels of auxin hormone on qualitative traits of forage sorghum Var. speed-feed, a split plot experiment in the form of randomized complete block design...