Abstract

Objective: To investigate the acute and sub acute toxicological evaluation of ethanolic extract of Tabernaemontana coronaria. Method: The acute toxicity profile as well as possible haemostatic activity of the ethanolic extract of the plant after sub acute oral administration was studied in male wistar albino rats.The rats were sacrificed 24 h after last treatment. Blood was collected by cervical decapitation for biochemical and haematological assessment. Liver and kidney were also excised, placed in 10% formalin for histopathological evaluation. Results: The ethanolic extract of Tabernaemontana coronaria did not produce any significant effect on haematology, lipid profile and renal profile. But only a slight increase in ALP and LDH is seen in group V rats. The histopathological study did not show any abnormalities in the liver and kidney. Conclusion: Although the ethanolic extract of Tabernaemontana coronaria has shown only slight increase in ALP and LDH activity in group 5 rats, the histopathological study confirmed the safety nature of the plant.

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