TOXICOLOGICAL IMPLICATIONS OF COMBINED CONSUMPTION OF HIGH FAT DIET AND ALCOHOL IN RATS
Journal Title: FLORA AND FAUNA - Year 2018, Vol 24, Issue 2
Abstract
The aim of the present study was to study the combined toxic effect of high fat diet and alcohol consumption on serological and oxidative stress markers in rats. Rats in control group received regular diet and water for 8 weeks, toxicant group were administered with 30% HFD and 10% alcohol for 2, 4, 6 and 8 weeks respectively.Combined consumption of high fat diet along with alcohol induced hepato-renal toxicity as evident by elevation of serum transaminases, alkaline phosphatase, bilirubin, cholesterol and triglycerides with significant decrease in glucose and albumin. Increased urea and uric acid was also seen in serum. Boosted lipid peroxidation and tissue biochemical parameters and decline in glutathione contents confirmed oxidative stress induced hepatorenal toxicity. Present study showed that 2, 4, 6 and 8 weeks administration of high fat diet along with alcohol significantly disturbed physiological integrity of liver and kidney.
Authors and Affiliations
HEMESHWER KUMAR CHANDRA, GITA MISHRA, NISHA SAHU, SATENDRA KUMAR NIRALA, MONIKA BHADAURIA
Keywords
Related Articles
- EP ID EP553188
- DOI 10.33451/florafauna.v24i2pp345-349
- Views 102
- Downloads 0
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