Toxicological Pathology of Aflatoxn B1 on Liver and Kidney in Broiler Chicks for Short Term
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 5
Abstract
A short term toxicological pathology study was done for six weeks on broiler chicks by feeding them on contaminated diets with aflatoxin B1, the birds were 14 days old at the start of the study there were macroscopic changes as enlarged and pale yellow liver, enlarged and hemorrhage of kidneys in most of the treated especially at the high dose level, histopathological changes were vacuolated hepatocytes and subcapsular region with areas of liver cell necrosis and areas of hemorrhage,periportal fibrosis and congestion of portal vein, septal fibrosis and mononeuclear cells also renal lesions with tubular necrosis, congestion, atrophy glomerular and degenerate vacuolate corticle tubules. In addition, there was hepatic bile duct proliferation with foci of hepatic oval cell proliferation too, those could reflect the carcinogenic effect of aflatoxin B1, as it could induced malignant liver cell tumor if the study continued for longer period.
Authors and Affiliations
Al-Sereah Bahaa. A
Keywords
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