Toxicological Properties of Disinfectants Based on Polyhexamethyleneguanidine — Forticept, Chisto, Polidez
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 80, Issue 4
Abstract
The objective of this work is to study the toxic properties of disinfectants Forticept, Chisto and Polidez in different routes of the exposure, to carry out a hygienic assessment of working conditions during disinfection activities to resolve the issue of the possibility of using them for their intended purpose. Methods of the study. Toxicological, hygienic, chemical and analytical, statistical. Results and their discussion. The toxicity parameters of disinfectants Forticept, Chisto and Polidez were determined when affecting laboratory animals in different ways. It was found that the formulation of these agents is less toxic than their active components (salts of polyhexamethyleneguanidine). The studied disinfectants belong to low-hazardsubstances in case of a single epidermal exposure (hazard class 4, GOST 12.1.007-76), moderately dangerous substances when ingested through the respiratory tract and gastrointestinal tract (hazard class 3, GOST 12.1.007-76). Irritant effect on the eye mucous membranes depends on the concentration of the active ingredient and the excipients included in their formulation. In case of repeated epidermal exposure, they do not have an irritating and unfavourable effect on the laboratory animals. The species sensitivity of laboratory animals to the effects of disinfectants was not observed. The results of sanitary and chemical studies showed that in different disinfection regimes, the active ingredient of these agents (PHMG-hydrochloride) was not observed in the air of the premises during and after treatment, after airing the room and on the surfaces (after cleaning with warm water). Conclusions. Toxic properties are more pronounced in Polidez-50, which contains two active components (PHMG-hydrochloride and PHMG-phosphate) than in agents with one active component — PHMG-hydrochloride (Forticept and Chisto). - When disinfectants contact the skin, they are classified as low-toxic substances — hazard class 4 according to GOST 12.1007-76 [41]. - Working solutions of Polidez, Forticept and Chisto that are used to disinfect objects are classified as low-risk substances. - A hygienic assessment of the use of Polidez-50 disinfectant in various disinfection regimes at the recommended rates of consumption showed that the active ingredient was not observed in the air of the premises during treatment and after ventilation, as well as on the treated surfaces. - Taking into account toxic parameters of Forticept, Chisto and Polidez in case of different routes of exposure, as well as the results of sanitary and chemical studies, it is possible to use them for target purpose as agents that provide bactericidal, fungicidal, tuberculosis and virucidal actions for disinfection of premises and surfaces (including floors, walls, dishes, etc.), and antiseptic treatment of open skin areas.
Authors and Affiliations
S. S. Svitlyi, V. M. Voronina, L. O. Rudaya
Keywords
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