Transcriptional networks and cell signals in embryonic development
Journal Title: Ege Tıp Dergisi - Year 2015, Vol 54, Issue 2
Abstract
The formation of the three lineages of the mouse blastocyst provides an important model system to study behavior of cells in the early stage of the development process, internal and external factors which play a role in this process and the interaction between them. With the establishment of a stable polarized outer epithelium, the signal differences between the inner and outer cells of the early cleavage stages lead to the establishment of the inner cell mass (embryoblast) and the trophectoderm. Events in the stages of embryonic development including cell polarity, cell position, effects of local microenvironment, transcriptional factors and their interaction processes are involved in determining cell fate. The slow pace of development of the mouse during this time, the ability to culture embryos, the development of tools for live cell imaging and the ability to modify the expression of genes that enable the elucidation of the process.
Authors and Affiliations
Eda AÇIKGÖZ, Hüseyin Aktuğ
Keywords
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