Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America - Year 2001, Vol 98, Issue 4
Abstract
Hepatotropism is a prominent feature of hepatitis B virus (HBV) infection. Cell lines of nonhepatic origin do not independently support HBV replication. Here, we show that the nuclear hormone receptors, hepatocyte nuclear factor 4 and retinoid X receptor alpha plus peroxisome proliferator-activated receptor alpha, support HBV replication in nonhepatic cells by controlling pregenomic RNA synthesis, indicating these liver-enriched transcription factors control a unique molecular switch restricting viral tropism. In contrast, hepatocyte nuclear factor 3 antagonizes nuclear hormone receptor-mediated viral replication, demonstrating distinct regulatory roles for these liver-enriched transcription factors.
Authors and Affiliations
H Tang, A McLachlan
Keywords
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- EP ID EP82863
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