TRANSDERMAL PATCHES OF CHITOSAN NANOPARTICLES FOR INSULIN DELIVERY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objectives: To develop a nanoparticle system with Chitosan for transdermal delivery of insulin.Methods: Chitosan and Tripolyphosphate (TPP) were used to prepare the insulin loaded chitosan nanoparticles based on ionotropic gelation method and characterized using Zeta-sizer Nano ZS, Scanning electron microscopy and Optical Microscope. Transdermal drug delivery system of the formulated Insulin-chitosan Nanoparticles was prepared using solvent casting method.Results: The results indicated that the nanoparticles were in the size range of 465 and 661 nm and exhibited quasi circular structure with better encapsulation efficiency. Controlled release Transdermal patches of insulin–chitosan nanoparticles were prepared using the polymer combinations HPMC, PVP K30 and PEG 400 with Tween 80 as plasticizer. The release rate of drug through patched increased simultaneously as the concentration of hydrophilic polymer was increased.Conclusion: The encapsulated insulin drug was very effectively released by patch F3.Â
Authors and Affiliations
Lingheswar Sadhasivam, Nibedita Dey, Arul Praksh Francis, Thiyagarajan Devasena
Keywords
Related Articles
- EP ID EP578784
- DOI -
- Views 74
- Downloads 0
RETROSPECTIVE STUDY ON THERAPEUTIC DRUG MONITORING OF LAMOTRIGINE IN INDIAN EPILEPTIC PATIENTS
Objective: Antiepileptic drugs (AED) are administered either singly or in combination with other drugs. Their pharmacokinetics is influenced by drug-drug interaction & inter-individual variations. Lamotrigine (LTG) i...
COMPARISON OF GENES EXPRESSION; MIRNA 146 A, MIR-103, MIR-423-3P, MIR-21, MIR-16 IN CELL LINES HEP-G2 SERIES 1886 AND PLC5
Objective: Detection of hepatocellular cancer cells(HCC) in vitro has reached the smallest level, that is miRNA(micro RNA) in particular miRNA146A. This study was conducted from February to May2013 at the Department of M...
PRELIMINARY STUDIES ON BRAIN TARGETING OF INTRANASAL ATOMOXETINE LIPOSOMES
Objective: The objective of the present study was to evaluate the enhancement in brain uptake of liposomes containing atomoxetine (ATX-Lipo) for intranasal delivery in the management of Attention Deficit Hyperactivity Di...
BIOACTIVITY GUIDED FRACTIONATION AND ANTI-INFLAMMATORY ACTIVITY OF ACACIA NILOTICA PODS
Objective: The present study aims at screening the methanol extract and the tannin fraction of the pods of Acacia nilotica for anti-inflammatory activity. Methods: The methanol extract and its tannin fraction were evalua...
PHYSICOCHEMICAL CHARACTERIZATION AND FLAVONOID CONTENTS OF ARTISANAL BRAZILIAN GREEN PROPOLIS
Objective: Green propolis (Baccharis dracunculifolia) is widely used in Brazilian folk medicine and elsewhere for treating varied illness. To address the need to meet its chemical composition and pharmacological effects,...