Trauma-Induced Systemic Inflammatory Response: A Comprehensive Review
Journal Title: Journal of Surgery Research and Practice - Year 2023, Vol 4, Issue 3
Abstract
Trauma is a noteworthy contributor to death and disability in adults. Its impact can extend to multiple organ systems via complex physiological reactions. This article comprehensively examines the physiological responses that transpire following trauma. It begins with the initial immune and inflammatory responses and advances to the possibility of sepsis and multi-organ dysfunction syndrome (MODS). The article delves into the roles of the innate and adaptive immune systems, the Systemic Inflammatory Response Syndrome (SIRS), and the various stages of sepsis. It emphasizes the importance of early detection and treatment, showcasing the benefit of the Injury Severity Score (ISS) to assess trauma severity and the Sequential Organ Failure Assessment (SOFA) scores to estimate sepsis severity. While acknowledging progress in understanding and identifying trauma-related conditions, the article emphasizes the importance of providing timely and accurate treatment to improve patient’s recovery.
Authors and Affiliations
M Mileković, A Ristić, LB Grošelj, I Rović, D Šijan, Ž Uskoković, K Petrović
Keywords
Related Articles
- EP ID EP720990
- DOI https://doi.org/10.46889/JSRP.2023.4301
- Views 44
- Downloads 0
Soft Tissue Sarcoma in a Malignancy Prone Patient: An Update
It is possible to encounter a patient who might have more than one type of a primary malignant tumor. The literature supports increasing tendencies for subsequent development of malignancies within same individual. A cas...
Magnitude and Associated Factor of Acute Appendicitis among Adult Patient Admitted At Hawassa University Comprehensive Specialized Hospital in Surgical Ward
Introduction: Acute Appendicitis (AA) refers to severe inflammation of the vermiform appendix, which is because of obstruction of the lumen of the appendix due to the inefficient emptying into the colon. In most parts of...
The Impact of COVID-19 on Patient Preferences in an Orthopaedic Clinic
Introduction/Purpose: Patient preferences for physician greeting method and attire are impactful but often overlooked aspects of the patient experience, which may be affected by the COVID-19 pandemic. In addition, the us...
Laminin 511-E8 Fragment Improves Second-Degree Burn Wound Healing in a Rat Model
Background: The rate of re-epithelialization is the primary determinant of the morbidity and mortality in patients with severe burn injuries. Laminin ⍺5β1γ1 (LM511) is an extracellular structural protein that can support...
Pediatric Tibial Shaft Fractures: A Comprehensive Review
Tibial shaft fractures are among the most common pediatric long bone fractures. These fractures have significant implications for growth, function and alignment, often requiring precise management to prevent complication...