Treatment Modalities for Basal Like Breast Cancer
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 12
Abstract
Breast cancer represents a heterogeneous group of disorders with significant morbidity and mortality among female population. Basal like breast cancer represents one of the several sub types of breast cancer. It has always been considered synonymous to triple negative breast cancer but studies have repeatedly proven it and triple negative to be two separate entities having different immunohisto chemistry, clinical behavior and prognosis. Basal like breast cancer represents an immunophenotype similar to triple negative breast cancer in a respect that it lacks estrogen receptors (ER), progesterone receptors (PR) and human epithelial growth factor 2 (HER2) overexpression, but is quite distinct at the same time as it represents additional biomarkers as well like cytokeratins 5/6 and epithelial growth factor receptors (EGFR). Moreover, basal like breast cancers is characterized as tumors with greater degree of atypia, higher propensity of local invasion, easy distant metastasis and grim prognosis. Even when it represent as much as 13-37% of breast cancer burden in young female population, definite treatment protocols remain lacking. Thorough analysis of currently available data in this regard has shown that breast conserving therapy (BCT) with adjuvant radiotherapy promises the best outcomes. In addition, preoperative use of chemotherapeutic agents like paclitaxel followed by 5-fluorouracil, doxorubicin, and cyclophosphamide and post-operative use of anthracycline (doxorubicin/cyclophosphamide or fluorouracil/doxorubicin/cyclophosphamide) and CMF based (Cyclophosphamide, Methotrexate, and Fluorouracil) adjuvant chemotherapy has shown to improve the prognosis. Furthermore, therapies that target features like dysfunction of BRCA1 and overexpression of EGFR are currently being studied as potential treatment options.
Authors and Affiliations
Dr. Adnan Bashir MD Bhatti,
Keywords
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