Treatment of critical-sized calvarial non-union defect via collagen-polyglycolic acid scaffold loading with simvastatin in rabbits
Journal Title: Iranian Journal of Veterinary Science and Technology (IJVST) - Year 2016, Vol 8, Issue 2
Abstract
The aim of the present study is to investigate the effects of a sustained-release simvastatin in collagen-polyglycolic acid scaffold on bone formation in the rabbit calvarial critical-sized defect. This study was carried out to examine if maximum bone regeneration with less inflammation would be attained by combining an optimal dose of simvastatin with Collagen-Polyglycolic acid scaffold, which is an osteoconductive biomaterial capable of releasing the drug slowly. To induce critical-sized calvarial defect in the 10 nominated adult New-Zealand rabbits we trephined four holes measured 5-mm-diameter into each head, and filled them with preparations of different doses of simvastatin (0.5 mg, and 1 mg) blended with Collagen-Polyglycolic acid, Scaffold alone or left empty. Five animals were sacrificed after 4 weeks and the rest of them after 8 weeks and examined histologically. Statistical analysis revealed that in the first time frame (the first four weeks), the difference between the control group and the simvastatin 0.5 mg group on one hand and the simvastatin 1 mg group and the control group on the other hand, there were statistically significant difference between (p < 0.05). In the second time frame (the next four weeks), there were statistically significant differences between the simvastatin 0.5 mg group and the control group, and between the scaffold group and the control group (p <0.05). When combined with collagen-polyglycolic scaffold, 0.5 mg simvastatin is the optimal dose for the arousal of the maximum bone regeneration in rabbit calvarial defects without causing inflammation and it could be applied as an effective bone graft material.
Authors and Affiliations
Hooman Mesgarani,Jebrail Movafagh,Hossein Nourani,Javad Behravan,Fatemeh Kalalinia,Hossein Kazemi Mehrjerdi,
Keywords
Related Articles
- EP ID EP722434
- DOI -
- Views 33
- Downloads 1
The investigation on the relationship between dairy cow hygiene scores and intramammary infections
The âcow hygiene scoreâ system is a management tool for assessment of cowâs body hygiene and cleaning of the barn. In this study, the correlation between body hygiene scores and intramammary infections (IMI), Calif...
Veterinary medicine and food animal practice in the era of footprints and “One-Health”: a descriptive approach
Our continually changing world has created new demands in society and has profoundly affected ecosystems, cultures, and professions. Ignoring the requirements and consequences of this ever-changing milieu could have deva...
Polydipsia/polyuria syndrome in a Congo African grey parrot (Psittacus erithacus erithacus):a case report
Polydipsia/polyuria syndrome is not a common manifestation in birds. Hyperglycemia was found on plasma chemistry in an African Grey Parrot (Psittacus erithacus), which was presented with polyphagia and self mutilation sy...
Effect of four local anesthetics (tetracaine, bupivacaine, lidocaine and proparacaine) on intraocular pressure in rabbits- Comparison of an applanation and a rebound tonometer
The type of device used, the type of local anesthetic agents, and the animal species may affect the intraocular pressure(IOP). Therefore, in order to determine these issues, the effects of four local anesthetics were inv...
The Histopathological Survey of Uterine Tissue in Holstein Dairy Cows with or without Recorded Reproductive Disorders
The objective of the study was to evaluate the uterine histopathological changes in Holstein dairy cows, within the range of 90-145 day in milk, with or without clinical history of reproduction system disorders. Lactatin...