Treatment of Lentigomaligna in Dark Skin with Topical Imiquimod Results in Dark Hyperpigmentation
Journal Title: International Journal of Clinical Dermatology & Research (IJCDR) - Year 2014, Vol 2, Issue 3
Abstract
LentigoMaligna (LM) is an in situ lesion with a low risk of progression to LM Melanoma (LMM). Treatment of LM is mostly advocated because an invasive component of LMM might be lethal. Recently topical Imiquimod 5% cream was introduced as a new treatment possibility. We describe here a patient, with skin type IV, with a hyperpigmented LM eruption at his forehead. The lesion was treated 4 weeks with topical Imiquimod 5%, 5 times a week for 8 weeks. Four weeks after cessation of treatment the macular lesion appeared enlarged and darker indicating lack of response. Punch biopsies revealed post-inflammatory hyperpigmentation (PIH) and ruled out LM and LMM. During 6 moths observation the skin normalized. The present case is a reminder that dark skin comprises an increased risk of PIH that when induced by Imiquimod treatment of LM can be mistaken as lack of therapeutic efficacy or progression to LMM.
Authors and Affiliations
Jesper Elberling
Keywords
Related Articles
- EP ID EP211256
- DOI 10.19070/2332-2977-140005
- Views 107
- Downloads 0
Dapsone in the Treatment of Epidermolysis Bullosa Acquisita Long - Term Follow - Up
Epidermolysis bullosa acquisita (EBA) is a rare, acquired, chronic subepidermal bullous disease of the skin and mucosa characterized by autoantibodies to type VII collagen structures, a major component of anchoring fibri...
Evalution Serum Zinc Level in Acne and Correlation with Severity Acne Vulgaris Benghazi - Libya
Background: Acne vulgaris is one of the most common cutaneous disorder affecting young and adolescents. Some investigators assessed the relationship between serum zinc levels and acne. Results of these studies suggest th...
Pigmented Basal Cell Carcinoma
Pigmented Basal Cell Carcinoma
Ophthalmic Zoster with Keratitis: A Rare Skin Disease in Children
Herpes zoster and varicella are the two main clinical presentations of the varicella zoster virus infection. Varicella is the manifestation of primary infection. It is a systemic infection, frequent in childhood. Herpes...
Validation of The Cardiff Acne Disability Index Questionnaire in Patients with Acne in Morocco
Background: Acne is a common distressing disease that can affect quality of life (QoL). The aim of the study was to translate and adapt the original version of the Cardiff Acne Distability Index (CADI) questionnaire from...