Treatment Outcome of Second Line Anti-retroviral Therapy in HIV Positive Patients Over One Year Period
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 9
Abstract
Introduction: In India, the second line regimen has still not been studied extensively when compared to it’s first line counterpart. In our study we accessed the clinical, virological and immunological effectiveness and treatment outcome over the one year of follow-up in our patients who were switched to the second line. Material and Methods: It was a prospective, observational study which included patients who were switched to second line ART from Jan2017 - Dec2017 at ART Centre of PMCH Dhanbad. Clinico-demographic details, symptoms, adverse drug reactions (ADRs), second line ART regimens, CD4 count, and plasma viral load (PVL) were recorded. Monthly follow-up was done. The data was analyzed by t-test, z-test, and Fisher-exact test. Results: Out of 100 patients, 70 received regimen I [zidovudine (ZDV) + lamivudine (3TC) + tenofovir (TDF) + boosted lopinavir (LPV/r)] and 30 received regimen II [3TC + TDF + LPV/r]. Significant (P < 0.0001) increase in mean body weight, marked reduction in viral load and those patients who were categorized in the WHO stage III/IV was observed at 12 months of second line ART. Significant improvement in immunity was observed clinically with an increase in mean CD4 count. Viral suppression (PVL < 400 copies/ml) was observed in 87 patients (P < 0.0001). A total of 74 ADRs were observed in 53 patients. Conclusion: Treatment outcome of second line ART was good as patients improved both clinically and improvement in laboratory data was also observed. Anemia was the most common ADR observed in the study.
Authors and Affiliations
Dharmendra Kumar Jha, Umesh Kumar Ojha, Anshu Kumar Jha
Keywords
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