Trends and Outcomes of Non-Small-Cell Lung Cancer in Omani Patients Experience at a university hospital
Journal Title: Sultan Qaboos University Medical Journal - Year 2017, Vol 17, Issue 3
Abstract
Objectives: Te incidence of lung cancer in Oman has shown a gradual but defnitive increase since 2002. Tis study aimed to evaluate the demographic and epidemiological characteristics and survival outcomes of patients with non-small-cell lung cancer (NSCLC) at a university hospital in Oman. Methods: Tis study was conducted from January to June 2016. A retrospective analysis was performed of consecutive patients diagnosed with NSCLC presenting to the Sultan Qaboos University Hospital (SQUH) in Muscat, Oman, between March 2000 and December 2015. Clinical features at presentation and prognostic and predictive markers were reviewed. Kaplan-Meir estimates were used to determine relapse-free survival, progression-free survival (PFS) and overall survival (OS). Results: A total of 104 patients presented to SQUH during the study period. Te median age at diagnosis was 64 years. Overall, 62 patients (59.6%) had adenocarcinomas. Only 12 patients (11.5%) presented in the early stages (I or II) of the disease and the majority of patients had an Eastern Cooperative Oncology Group performance status of 1 (27.9%) or 2 (26.0%). Te prevalence of epidermal growth factor receptor mutations was 27.9%. Te median PFS for patients with advanced disease (stages III or IV) was fve months and the median OS for all patients was seven months. After fve years, 50.0%, 60.0%, 10.0% and 8.0% of patients with disease stages I, II, III and IV, respectively, were alive. Conclusion: Patients with NSCLC in Oman were found to present at an advanced stage. However, patient outcomes were similar to those reported in the USA.
Authors and Affiliations
Muhammad Furrukh| Department of Medicine, Shifa College of Medicine, Islamabad, Pakistan, Shiyam Kumar| Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman, Khawaja F. Zahid| Te Queen’s Centre for Oncology & Haematology, Castle Hill Hospital, Cottingham, East Yorkshire, UK, Hanan S. Al-Shamly| Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Zainab A. Al-Jabri| Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Ikram A. Burney| Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman, Mansour S. Al-Moundhri| Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
Keywords
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- EP ID EP14793
- DOI 10.18295/squmj.2017.17.03.007
- Views 390
- Downloads 18
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