TRENDS IN AETIOLOGY AND SUSCEPTIBILITY PATTERN OF BACTERIAL PATHOGENS FROM BLOODSTREAM INFECTIONS AT A TERTIARY CARE TEACHING HOSPITAL IN WESTERN MAHARASHTRA- A 4-YEAR ANALYSIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 70
Abstract
BACKGROUND Bloodstream infections (BSIs) are life-threatening. Microbiological cultures take time for reporting. It is essential to start initial appropriate empirical treatment to reduce morbidity and mortality due to septicaemia. One should know the local epidemiology and susceptibility pattern of the isolates to decide appropriate empirical therapy. MATERIALS AND METHODS A retrospective analysis of data from blood cultures was done over a period of 4 years at a tertiary care teaching hospital. Trends in bacterial aetiology and susceptibility pattern was studied. RESULTS A total of 1651 bacterial isolates were obtained from 12553 blood cultures over 4-year period from 2011 to 2014. Gram negative bacteria (75.4%) predominated the gram-positive bacteria, 21.44% as aetiological agents of sepsis. Amongst Gram negative bacteria, E. coli in 2011 (60%) and Klebsiella pneumonia (44%), Citrobacter spp. (45%) were predominant in 2012. There was emergence of Acinetobacter spp. (22%) and Pseudomonas aeruginosa (19.5%) as main aetiological agent of sepsis in 2012 and 2013. Analysis of Gram positive bacteria showed Staphylococcus aureus (33.3%) as predominant aetiological agent followed by Coagulase negative staphylococci (29.3%) and Enterococci (26.5%). Increase in multidrug resistant pathogens was observed over the years with 60% of the isolates being MDR. The percentage of ESBL producing GNB was ranging between 60% - 62%, while that of Amp C and Metallobetalactamase producers were ranging between 69% - 71% and 13.5% - 21% respectively. Amongst gram positive Vancomycin resistance was not seen in staphylococci, but was observed in Enterococci (2% to 5%). All gram positive cocci were 100% sensitive to Linezolid. CONCLUSION Knowing the local epidemiology and susceptibility of pathogens causing septicaemia is important to decide initial appropriate treatment in order to improve the clinical outcome of sepsis.
Authors and Affiliations
Mudshingkar Swati, Palewar Meghna, Dohe Vaishali, Bhardwaj Renu
Keywords
Related Articles
- EP ID EP233447
- DOI 10.14260/Jemds/2017/1084
- Views 109
- Downloads 0
A CASE OF ALTERED SENSORIUM WITH MOVEMENT DISORDER
PRESENTATION OF CASE Hemichorea generally occurs due to stroke, neoplasm or granuloma in the contralateral basal ganglia.(1) Metabolic derangements especially hyperglycaemia can also cause focal neurological dysfunction...
EVALUATION OF MEAN PLATELET VOLUME AS A PROGNOSTIC MARKER IN TYPE II DIABETES MELLITUS
[b]BACKGROUND:[/b] Diabetes mellitus (DM) is both metabolic disorder and a major worldwide health problem because of its high prevalence and mortality. The prevalence of cardiovascular complication of type II D...
POSTOPERATIVE ANALGESIA IN PAEDIATRICS PATIENTS THROUGH CAUDAL BLOCK WITH BUPIVACAINE AND TWO DIFFERENT DOSES OF FENTANYL - A COMPARATIVE STUDY.
[b] BACKGROUND[/b]: Narcotics have been used through caudal epidural route to supplement the effects of local anesthetics. [b]MATERIALS & METHODS:[/b] This prospective, comparative study was carried out in a med...
POST CHOLECYSTECTOMY AND THE DYSPEPTIC PATIENT TO IDENTIFYING THE APPROPRIATENESS OF OPERATIVE INTERVENTION IN CHENGALPATTU MEDICAL COLLEGE
BACKGROUND Dyspepsia is defined by the discomfort or pain localised in the upper abdomen. This pain is common with a prevalence of forty to sixty percent in the general population. But often 55% of patients do not have a...
HISTOPATHOLOGY AND BACTERIOLOGY IN HANSEN’S DISEASE
BACKGROUND Leprosy is a disease, which has been associated with tremendous social stigma with cases recorded in the Old Testament. It is an infectious disease caused by Mycobacterium leprae. Leprosy expresses itself in d...