TRENDS IN AETIOLOGY AND SUSCEPTIBILITY PATTERN OF BACTERIAL PATHOGENS FROM BLOODSTREAM INFECTIONS AT A TERTIARY CARE TEACHING HOSPITAL IN WESTERN MAHARASHTRA- A 4-YEAR ANALYSIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 70
Abstract
BACKGROUND Bloodstream infections (BSIs) are life-threatening. Microbiological cultures take time for reporting. It is essential to start initial appropriate empirical treatment to reduce morbidity and mortality due to septicaemia. One should know the local epidemiology and susceptibility pattern of the isolates to decide appropriate empirical therapy. MATERIALS AND METHODS A retrospective analysis of data from blood cultures was done over a period of 4 years at a tertiary care teaching hospital. Trends in bacterial aetiology and susceptibility pattern was studied. RESULTS A total of 1651 bacterial isolates were obtained from 12553 blood cultures over 4-year period from 2011 to 2014. Gram negative bacteria (75.4%) predominated the gram-positive bacteria, 21.44% as aetiological agents of sepsis. Amongst Gram negative bacteria, E. coli in 2011 (60%) and Klebsiella pneumonia (44%), Citrobacter spp. (45%) were predominant in 2012. There was emergence of Acinetobacter spp. (22%) and Pseudomonas aeruginosa (19.5%) as main aetiological agent of sepsis in 2012 and 2013. Analysis of Gram positive bacteria showed Staphylococcus aureus (33.3%) as predominant aetiological agent followed by Coagulase negative staphylococci (29.3%) and Enterococci (26.5%). Increase in multidrug resistant pathogens was observed over the years with 60% of the isolates being MDR. The percentage of ESBL producing GNB was ranging between 60% - 62%, while that of Amp C and Metallobetalactamase producers were ranging between 69% - 71% and 13.5% - 21% respectively. Amongst gram positive Vancomycin resistance was not seen in staphylococci, but was observed in Enterococci (2% to 5%). All gram positive cocci were 100% sensitive to Linezolid. CONCLUSION Knowing the local epidemiology and susceptibility of pathogens causing septicaemia is important to decide initial appropriate treatment in order to improve the clinical outcome of sepsis.
Authors and Affiliations
Mudshingkar Swati, Palewar Meghna, Dohe Vaishali, Bhardwaj Renu
Keywords
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- EP ID EP233447
- DOI 10.14260/Jemds/2017/1084
- Views 103
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