Triggering apoptosis in tumors: an overview of potential approaches in treatment of leukemia
Journal Title: Genetics & Applications - Year 2019, Vol 3, Issue 1
Abstract
Apoptosis, as a well-studied process of a programmed cell death, is essential for the maintenance of cell homeostasis and integrity of organisms. This process occurs normally during development and aging and it is a balance of the sustainability of the tissue cell population. In addition, apoptosis also occurs as a defensive mechanism such as an immune response or after cell damage as a consequence of a pathological condition or the action of harmful agents. Apoptotic activation tends to be less responsive with aging, causing accumulation of non-functional cells and pathological changes such as degenerative diseases or tumor transformation. This overview aims to provide summarized facts about different approaches of apoptosis research, targeting and regulation in tumors especially in leukemic cells as a way of pharmacological manipulation with a potential therapeutic benefit.
Authors and Affiliations
Maida Hadžić, Sanin Haverić, Lejla Pojskić
Keywords
Related Articles
- EP ID EP592343
- DOI 10.31383/ga.vol3iss1pp3-13
- Views 132
- Downloads 0
PREDICTION OF THE SIZE OF NANOPARTICLES AND MICROSPORE SURFACE AREA USING ARTIFICIAL NEURAL NETWORK
This paper presents development of Artificial Neural Network (ANN) for prediction of the size of nanoparticles (NP) and microspore surface area (MSA). Developed neural network architecture has the following three inputs:...
Flow cytometry as tool in plant sciences, with emphasis on genome size and ploidy level assessment
Flow cytometry has become the method of choice to measure the DNA content (genome size) in plants. Ease of sample preparation, fast acquisition, and accurate measurements have made the method popular in the domains of pl...
Copy number variation in MODY diabetes - familial case presentation
MODY (Maturity-Onset Diabetes of the Young) is an autosomal dominant form of diabetes that usually have onset in adolecence. This type of diabetes is caused by defects in the primary insulin secretion. Different types of...
AIR POLLUTION TOLERANCE INDEX OF Plantago major IN STEELWORKS AREA OF ZENICA, BOSNIA AND HERZEGOVINA
Atmospheric pollution is among the largest anthropogenic impacts on the ecosystem. In numerous studies it was observed that plants, especially those that grow in urban areas, are heavily influenced by different pollutant...
New insights into the antifungal activity of Taxus baccata L.
Taxus baccata L., yew, is dioecious, small to medium-sized evergreen tree, native to Europe, Africa and Asia, but it is cultivated worldwide because of its ornamental features. It is long known that all parts of yew (exc...