Triggering Receptor Expressed on Myeloid Cells-1 and Clinical Disease Activity in Patient with SLE Nephritis 24 Months Follow-Up Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Objective: Is the TREM-1 can be used as a predictor of early disease activity or follow-up of a lupus patient. SLE pathogenesis is a multifactorial disease, the Traditional biomarker used in an everyday assessment of SLE patients such as ANA, Anti-DNA, C3, C4, creatinine clearance, and kidney biopsy. TREM-1 is a member of the immunoglobulin super family with an established role in innate and adaptive immune response and possible role in SLE nephritis. Methods: thirty-five SLE patients classified according to SLICC Revised Criteria for Diagnosis of SLE 2012 and 20 healthy control group. All patients underwent full clinical and lab assessment and kidney biopsy were taken through the study according to clinical assessment of SLE activity with consent taken. TREM-1 was done for all patient group at an early study and after 24 months of SLE disease activity. Results: this results showed increased level of TREM-1 early and marked elevation at the end of the study and highly significant difference within the patients and between patient and study group P<0.05. There is a positive correlation between TREM-1 and renal biopsy and anti-DNA, C3, C4 SELENA score Conclusion: TREM-1 can be used as biomarkers for monitoring and/or predicting SLE disease activity but, needs to be further investigated with large-scale multicenter trials. A combination of novel markers with conventional clinical parameters to enhance the sensitivity and specificity for the early prediction of renal disease/flares and prognosis in patient with lupus nephritis
Authors and Affiliations
Sami Abdulhakim
Keywords
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