Triple Malignancy Involving Breast, Ovary and Uterine Vault: A Case Report and Literature Review
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: The occurrence of two or more primary malignant neoplasms in the same person is rare. We have a case report of a 45-year-old woman with triple malignancy involving breast, ovary and uterine vault being managed at our center since 5 years. Case Report: Our patient presented as a post operated case of two primary malignant neoplasms of carcinoma breast and ovary. For carcinoma ovary she underwent adjuvant chemotherapy and interval cytoreductive surgery. For carcinoma breast she received adjuvant locoregional radiotherapy and chemotherapy. After latent period of 42 months, patient was diagnosed with squamous cell carcinoma vault for which she received pelvic radiotherapy. After around one year she developed locoregional recurrence of vault carcinoma. She received six cycles of palliative chemotherapy and is on regular follow-up. Our patient presented with two synchronous primary malignancies and one metachronous malignancy. Two primary malignancies were carcinoma ovary and breast. She was diagnosed with the third malignancy (carcinoma uterine vault) when she was in regular follow-up and the two previous primaries were controlled. This emphasizes the importance of a regular follow-up and the need of a meticulous work-up for early diagnosis and prompt management of any metachronous malignancy. Conclusion: Regular follow-up with suspicion of any metachronous primary malignancy and prompt diagnostic workup to detect them at early stage is very crucial for better outcome. Moreover the choice of appropriate treatment strategy remains the cornerstone in management of patients with multiple primary malignancies.
Authors and Affiliations
Mohammad Shadab Alam, Roshan Perween, Shahid A Siddiqui
Keywords
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