Triple negative breast cancer – Our experience
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 8
Abstract
Triple negative Breast cancer constitutes 10-25% of patients with Breast cancer. TNBC is an aggressive phenotype and has poor prognosis. We restrospectively analysed 30 triple negative Breast cancer patients attending our out patients department among 200 Breast cancer Patients. The incidence of TNBC was 15% and most of them were post menopausal 73.33% (22/30) with mean age was 54.96 (Range 98-74 years) Most of them had Invasive ductal cancer 100% (30/30) and were high grade 3 (86.66%) (26/30). 2 patients (6.66%) presented with metastatic disease. one patient with lung metastasis and one patient with locally advanced disease with fungating mass over Breast and liver metastasis. 15 patients (50%)developed Recurrence and Distant metastasis on follow up. 2 patients had chest wall Recurrence, 1 had chest wall recurrence with lung metastasis,4 had Bone metastasis, 1 had lung metastasis, 1 had lung metastasis with contralateral breast cancer, 1 had liver mestastasis with contralateral Breast Cancer, 1 had lung with Bone and Brain metastasis, 1 had lung with liver, Brain and adrenal metastasis, and 1 had chest wall recurrence with supraclavicular lymph node reccurence with Bone metastasis, 1 had chest wall recurrence with supraclavicular lymph node recurrence with lung and Bone metastasis, 1 had supraclavicular lymph node recurrence. The mean disease free survival was 19.8 months (range 3-52 months) and overall survival was 27.3 months (range 9-98 months). 4 patients (13.33%) died during follow up. Hence Triple Negative Breast cancer is aggressive with rapid progression leading to mortality in younger patients.
Authors and Affiliations
Veenu Agrawal, Tejal Vadhan, S Shewalkar, A Gaikwad
Keywords
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