Triterpenoids from Poria cocos and Their Potential In vitro Hepatoprotective Effects
Journal Title: Journal of Complementary and Alternative Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Aims: To isolate triterpenoids from the surface layer of Poria cocos and evaluate their hepatoprotective activities in vitro. Study Design: Triterpenoids were isolated and identified from the surface layer of Poria cocos. Their effects on alcohol induced-liver injury models were investigated in vitro. Place and Duration of Study: School of Pharmacy, Guangdong Pharmaceutical University, between September 2013 and December 2013. Methodology: Triterpenoids were purified by Silica gel, ODS as well as HPLC chromatography and characterized by MS, 1D and 2D NMR. The hepatoprotective effects of the isolated compounds against alcohol induced-liver injury were investigated in L-02 cell line. Results: Eight triterpenoids were isolated and identified from the surface layer of Poria cocos (1–8), Compounds 2, 3, 6 showed potent protective effects against ethanol-induced injury on L-02 cells. Conclusion: This study suggests that triterpenoids from the surface of Poria cocos could protect L-02 cells from death induced by alcohol and suitable for alcohol induced-liver injury patients as medicine or functional food, which would be a new candidate for the treatment of alcoholic liver disease.
Authors and Affiliations
Yihai Wang, Guoqiong Wang, Xiaomin Yi, Xiangjiu He
Keywords
Related Articles
- EP ID EP337160
- DOI 10.9734/JOCAMR/2017/38016
- Views 48
- Downloads 0
In vitro Assessment of Selected Antibiotics, Crude Extract of Dalbergia latifolia Leaf and Their Combination on MDR Salmonella enterica Strain
Aims: To investigate the susceptibility pattern Salmonella enterica strains to selected antibiotics and extract of Dalbergia latifolia as well as their combinatory effect on (multi-drug resistant) MDR salmonella. Place...
Phytochemical Analysis and Anticholinergic Properties of Methanol Leaf Extract of Arachis hypogea on Isolated Rabbit Jejunum
The acute toxicity and parasympatholytic properties of methanol extract of Arachis hypogea leaves were studied in vitro and in vivo. Qualitative phytochemical screening revealed the presence of alkaloids, glycosides, fat...
Cupping Therapy (Al-Hijamah) Points: A Powerful Standardization Tool for Cupping Procedures?
Background: Cupping (Al-Hijamah) therapy is a traditional complementary and alternative medicine practice used in diverse diseases with the variable outcome since ancient times. The precise selection of cupping points is...
In-vitro DPPH Free Radical Scavenging Activity of the Plant Murraya koenigii Linn (Curry Leaf) in Rajshahi, Bangladesh
Aim: The use of herbal medicine is becoming popular day by day due to toxicity and side effects of allopathic medicines and hence the present study was carried out to assess the in-vitro DPPH free radical scavenging pote...
Cellular Effects Following Exposure to Wireless DECT Base Radiation and Presentation of a Device for Their Compensation
Background: Wireless telecommunication sources working with frequencies ranging from 0.9 to 2.5 GHz are still increasing rapidly. Among these are digitally enhanced cordless telecommunication (DECT) phones which have bee...