Triticum aestivum (wheat grass) Exhibited Anticancer Activity on Oral Cancer (KB) Cell Line
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2020, Vol 8, Issue 5
Abstract
Objective:Currently oral cancer is the sixth most common cancer in the world with a quarter of world burden being borne by India. Wheat grass, a traditional medicine is used worldwide to treat various ailments, with its anticancer activity being reported on few celllines like Hep2, Hela and K562.Aim: Aim of this study was to evaluate the anticancer and cytotoxic activity of WG on oral cancer (KB) cells and mouse embryonic cells (NIH3T3) respectively.Methods and Material: Standard KB and NIH3T3 cells lines were procured. Ethanol extractof freshly grown WG was prepared in our laboratory and commercially available powder ofWG was also procured. Anticancer activity on KB cells and cytotoxic activity on NIH3T3 cells was evaluated by MTT assay with the two forms of WG.Statistical analysis used: Statistical analysis was performed by using spearman’s coefficient correlation to correlate the concentration of extract and cell inhibition.Results: WG exhibited an inhibition of KB cells in a dose-dependent manner with an IC50value of 156μg/ml and was non-toxic on NIH3T3 cells.Conclusion: WG showed anticancer activity on KB cells and therefore can be considered for further studies on animals and eventually on human beings.
Authors and Affiliations
Sanjeevini A Hattarki, Chetna Bogar, Kishore Bhat
Keywords
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