Trophoblast invasion.
Journal Title: Human Fertility - Year 2005, Vol 7, Issue 3
Abstract
Trophoblast invasion can be seen as a tightly regulated battle betweenthe competing interests of the survival of the fetus and those of the mother. Successful pregnancy isdependent on the trophoblast invading the mother, attaching the pregnancy to the uterus and securingan adequate supply of oxygen and nutrient to the fetus. For successful invasion to occur, extravilloustrophoblast has to perform a range of functions; transformation of the maternal spiral arteries, toleratehypoxia, proliferate and die by apoptosis (programmed cell death), differentiate, adhere to and digestthe extracellular matrix, move and interact with the maternal immune system. Each of these functionshas multiple overlapping control systems so that trophoblast invasion is a finely controlled balanceof competing mechanisms.
Authors and Affiliations
Sheba Anin Anin, Gill Vince, Siobhan Quenby
Keywords
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- EP ID EP82402
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Trophoblast invasion.
Trophoblast invasion can be seen as a tightly regulated battle betweenthe competing interests of the survival of the fetus and those of the mother. Successful pregnancy isdependent on the trophoblast invading the mother,...