Tumor Microenvironment: A Review
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 5
Abstract
The microenvironment of a tumor is an integral part of its physiology, structure, and function. It is an essential aspect of the tumor proper, since it supplies a nurturing environment for the malignant process. A fundamental deranged relationship between tumor and stromal cells is essential for tumor cell growth, progression, and development of life threatening metastasis. Non-malignant cells and secreted proteins from tumor and stromal cells are active participants in cancer progression. A growing number of studies demonstrate a positive correlation between angiogenesis, carcinoma-associated fibroblasts, and inflammatory infiltrating cells and poor outcome, thereby emphasizing the clinical relevance of the tumor microenvironment to aggressive tumor progression. Improved understanding of this interaction may provide new and valuable clinical targets for cancer management, as well as risk assessment and prevention. Thus, the dynamic and reciprocal interactions between tumor cells and cells of the tumor microenvironment orchestrate events critical to tumor evolution toward metastasis, and many cellular and molecular elements of the microenvironment are emerging as attractive targets for therapeutic strategies.
Authors and Affiliations
Dr. Shivani Singh
Keywords
Related Articles
- EP ID EP505965
- DOI -
- Views 122
- Downloads 0
Bacterial Infections In Hospitalized Patients With Liver Cirrhosis In A Tertiary Care Hospital
Background And Aim: Patients with liver cirrhosis have a high risk of developing bacterial infections. The prevalence of bacterial infections is about 25-39% in hospitalized cirrhotic patients. There is scarcity of repor...
Role of vitamin D in conversion of free T4 to T3: A hospital based cross sectional study
Introduction and Objective:Few speculations are made regarding the conversion of T4 to T3 using vitamin D. Studies show that thyroid hormone inhibits 25 (OH) D l alpha hydroxylase and the latter also suppresses TSH secre...
Comprehensive dental management of visually impaired children: A brief review
Vision is one of the primary senses that help a child construe his/her environment during the early years of life, the absence of which may have damaging effects on their overall development. Oral health care needs of vi...
Epigenetic regulation of 5Hydroxy methyl cytosine region in the CpG Island of Brain derived neurotropic factor in human type II diabetes Retinopathy: An in silico approach
Epigenetic modulations play essential roles in diverse biological processes. During the past several years, DNA demethylation has been discovered in embryonic and postnatal development. Although some potential functions...
Reconstruction of the mandible using free fibula flap
Purpose: To review the reconstruction of the mandible through vascularised free fibula flap through anatomical considerations, preoperative evaluation, reconstruction plates, microvascular anastomosis, stereolithographic...