TUMOR PREVENTIVE POTENTIAL OF CROMOLYN IN 7, 12DIMETHYLBENZ(A)ANTHRACENE INDUCED HAMSTER BUCCAL POUCH CARCINOGENESIS
Journal Title: International Journal of Pharma and Bio Sciences - Year 2016, Vol 7, Issue 1
Abstract
Cromolyn explored diverse pharmacological effects including antioxidant, anti-inflammatory and anticancer properties. The cytotoxic or anti-cell proliferative potential of cromolyn has been well documented in various cancer cell lines. To date, there are no studies on the chemopreventive potential of cromolyn against 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinogenesis. The chemopreventive efficacy of the cromolyn was substantied with the incidence of tumor formation, histological abnormalities and by analysing the status of biochemical markers such as lipid peroxidation by products, antioxidants and phase I and II detoxification agents in DMBA induced hamster buccal pouch carcinogenesis. Well differentiated squamous cell carcinoma was noticed in the buccal pouches of hamsters treated with DMBA (three times a week for 14 weeks). Cromolyn completely prevented the tumor formation and restored the status of biochemical markers in the pre-initiation phase. Also cromolyn reduced the tumor size and burden as well as improved the status of biochemical markers in the postinitiation phase. The present results thus implicate the tumor preventive potential of cromolyn in DMBA induced hamster buccal pouch carcinogenesis.
Authors and Affiliations
SEKAR KARTHIKEYAN, Shanmugam Manoharan
Keywords
Related Articles
- EP ID EP576129
- DOI -
- Views 103
- Downloads 0
BIOFABRICATION OF SILVER NANOPARTICLES FROM FRUITS WASTE EXTRACT AND THEIR APPLICATION TOWARDS ANTIMICROBIAL ACTIVITY
The development of uniform nanoparticles has been intensively pursued because of their technological and fundamental scientific importance. In this work, we have formulated a simple and effective procedure for biofabrica...
BIOASSAY GUIDED ISOLATION AND IDENTIFICATION OF THE ANTIOXIDANT CONSTITUENT FROM HOLOSTEMMA ADA-KODIEN SHCULT
Holostemma ada-kodien shcult (Syn: Holostemma annulare) is a traditionally used in Indian herbal medicine. The objective of this study is to investigate the antioxidant activity of a bioassay-guided fractionation and its...
SIMULTANEOUS ESTIMATION OF BISOPROLOL FUMARATE AND CILNIDIPINE IN TABLET DOSAGE FORM USING RP-HPLC METHOD
A simple and precise Reverse-phase high performance liquid chromatography method has been developed and validated for simultaneous estimation of Bisoprolol fumarate (BISO) and Cilnidipine (CIL) in tablet dosage forms. Th...
IN VITRO GERMINATION OF ANTI-DIABETIC PLANT LOQUAT (Eriobotrya japonica Lindl.) TO PRODUCE GOOD SEEDLING
The aim of the study is to obtain good seedling of anti-diabetic plant Loquat (Eriobotrya japonica Lindl.) through in vitro germination by using growth stimulator of gibberellic acid (GA3) and kinetin. The study is carri...
TUMOR PREVENTIVE POTENTIAL OF CROMOLYN IN 7, 12DIMETHYLBENZ(A)ANTHRACENE INDUCED HAMSTER BUCCAL POUCH CARCINOGENESIS
Cromolyn explored diverse pharmacological effects including antioxidant, anti-inflammatory and anticancer properties. The cytotoxic or anti-cell proliferative potential of cromolyn has been well documented in various can...