Tumour Necrotic Factor Alpha, Interleukin 4 AndInterleukin 6 Levels In Patients With Prostatic Enlargements in A Nigerian Tertiary Hospital.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Objectives: To determine the levels of TNF-α, IL-4 and IL-6 in the plasma of patients with benign and malignant prostate enlargements in Port Harcourt. Subjects and Methods: Plasma of 30 patients with benign prostate enlargement, 30 patients with malignant prostate enlargement and 20 healthy controls at the University of Port Harcourt Teaching Hospital (UPTH) were analysed with the ELISA method to determine the levels of TNF-α, IL-4 and IL-6. The ages, PSA levels and volume of the prostate gland were retrieved from the patients’ case notes and analyzed along with the levels of the cytokine using the SPSS version 21. Results: The mean age of the patients with benign lesion (65.5±1.8)years was lower than those with malignant enlargement (67.5±1.5)years, but was not statistically significant. The average PSA level was also significantly higher (p < 0.05) in malignant enlargements (76.3±6.9ng/ml) when compared to benign prostate enlargement (3.3±0.3ng/ml). The mean plasma concentrations of TNF-α, IL-4 and IL-6 in patients with benign lesions were 73.3±7.4 (±SEM), 47.9±15.2 (±SEM) and 15.4 ± 2.1 (±SEM) respectively while that for malignant lesions were 38.1± 1.7 (±SEM), 4.4± 0.5 (±SEM) and 1.9± 0.2 (± SEM) respectively. The values were statistically significantly higher in patients with benign enlargement than those with malignant enlargement. Conclusion: The plasma concentrations of TNF-α, IL-4 and IL-6 were found to be higher in patients with benign prostate enlargement than those with malignant enlargement in our environment.
Authors and Affiliations
Dr. Olufemi G Omitola, Dr. Onyeanunam N Ekeke, Prof Anthonia A Okerengwo
Keywords
Related Articles
- EP ID EP250474
- DOI 10.9790/0853.1612025356
- Views 79
- Downloads 0
Analysis of Cases Admitted with Fever with First Time Seizures Within Age Group of 3 to 12 Months
It is essential to exclude underlying meningitis in all children with febrile seizures (FS) either clinically or if uncertain by lumbar puncture (LP) because majority of such cases of meningitis are bacterial in origin a...
Diagnostic Utlilty of FNAC in breast lesions and its correlation with histopathology
Background- A palpable breast lump is a common diagnostic problem to both general practitioners and surgeons. FNAC is a valuable tool and it's advantage is to provide rapid accurate diagnosis, cost-effective, excellent p...
“The Patient Knows Best”- Evaluation Of Distal Radial Fracture Locking Plate Fixations Using The Patient Rated Wrist Evaluation.
Fractures of distal end radius account for one sixth of all fractures that are seen and treated by orthopaedic surgeons.Although most of them were managed conservatively in the past,recently they have become the focus of...
Prevalence of Depression And Its Associated Factor With Coping Strategies Among Medically Ill Elderly Patients In Eastern Rajasthan Jaipur
Background: Depression is recognized as a serious public health concern in developing countries. It is the most common psychiatric disorder among the elder person. There is a relationship between coping and depression. I...
QT Dispersion-An Ignored Screening Tool For Cardiovascular Disease In Diabetics
Background: Diabetes Mellitus Type 2 is a major global non-communicable disease among adults causing micro and macrovascular complications, one being cardiovascular system. QT dispersion represents the summation of sever...