Tumour Necrotic Factor Alpha, Interleukin 4 AndInterleukin 6 Levels In Patients With Prostatic Enlargements in A Nigerian Tertiary Hospital.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Objectives: To determine the levels of TNF-α, IL-4 and IL-6 in the plasma of patients with benign and malignant prostate enlargements in Port Harcourt. Subjects and Methods: Plasma of 30 patients with benign prostate enlargement, 30 patients with malignant prostate enlargement and 20 healthy controls at the University of Port Harcourt Teaching Hospital (UPTH) were analysed with the ELISA method to determine the levels of TNF-α, IL-4 and IL-6. The ages, PSA levels and volume of the prostate gland were retrieved from the patients’ case notes and analyzed along with the levels of the cytokine using the SPSS version 21. Results: The mean age of the patients with benign lesion (65.5±1.8)years was lower than those with malignant enlargement (67.5±1.5)years, but was not statistically significant. The average PSA level was also significantly higher (p < 0.05) in malignant enlargements (76.3±6.9ng/ml) when compared to benign prostate enlargement (3.3±0.3ng/ml). The mean plasma concentrations of TNF-α, IL-4 and IL-6 in patients with benign lesions were 73.3±7.4 (±SEM), 47.9±15.2 (±SEM) and 15.4 ± 2.1 (±SEM) respectively while that for malignant lesions were 38.1± 1.7 (±SEM), 4.4± 0.5 (±SEM) and 1.9± 0.2 (± SEM) respectively. The values were statistically significantly higher in patients with benign enlargement than those with malignant enlargement. Conclusion: The plasma concentrations of TNF-α, IL-4 and IL-6 were found to be higher in patients with benign prostate enlargement than those with malignant enlargement in our environment.
Authors and Affiliations
Dr. Olufemi G Omitola, Dr. Onyeanunam N Ekeke, Prof Anthonia A Okerengwo
Keywords
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- EP ID EP250474
- DOI 10.9790/0853.1612025356
- Views 53
- Downloads 0
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