Title Abstract Introduction Case 1 Case 2 Discussion Conclusion References Citation Case Report Two Cases of Pure Hair Nail Ectodermal Dysplasia in Two Yemeni Siblings Mohammad Ali Alshami1* Mona Jameel Mohana1 and Ahlam Mohammad Alshami2 1Dermatology Department Faculty of medicine and health sciences Sana’a University Sana’a Yemen 2Faculty of Dentistry Sana’a University Sana’a Yemen *Address for Correspondence: Mohammad Ali Alshami Dermatology Department Faculty of medicine and health sciences Sana’a University Sana’a Yemen Tel: 00967733760082; E-mail: mohammadalshami62@gmail.com Citation: Alshami MA Mohana MJ Alshami AM. Two Cases of Pure Hair Nail Ectodermal Dysplasia in Two Yemeni Siblings Two Cases of Pure Hair Nail Ectodermal Dysplasia in Two Yemeni Siblings. J Clin Investigat Dermatol. 2016;4(2): 3. Copyright © 2016 Alshami MA et al. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Journal of Clinical & Investigative Dermatology | ISSN: 2373-1044 | Volume: 4 Issue: 2 Submission: 08 June 2016| Accepted: 02 July 2016 | Published: 06 July 2016 Reviewed & Approved by: Dr. Taihao Quan Department of Dermatology University of Michigan USA Abstract Ectodermal dysplasias (ED) are a rare group of genodermatoses affecting tissues of ectodermal origin namely: hair nails teeth and sweat glands. Pure hair nail ectodermal dysplasias (PHNED) are very rare and involve only hair and nails while other ectodermal structures are intact. To date only 20 cases have been reported inthe world literature. We report two cases of PHNED in a 15 years old Yemeni boy and his 2 months old sister who were born with total absence of hairs and dystrophic 20 nails. All other family members were not affected. Keywords Skin; Hair; Nail; Ectodermal dysplasia